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Technology
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Services
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Drug Development Partnerships
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Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
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Custom Model & Assay Development
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We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
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Compound profiling & Screening
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Get robust compound data in human tissue models through our services. With proven phenotypic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
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All Services
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We offer several services to support your drug discovery and development needs. Find the overview here.
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Products
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OrganoPlate®
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OrganoPlate® 2-lane 96
Supporting up to 96 tissue models on a single plate.
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OrganoPlate® 3-lane 40
Supporting up to 40 tissue models on a single plate.
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OrganoPlate® 3-lane 64
Supporting up to 64 tissue models on a single plate.
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OrganoPlate® Graft
The first in vitro tissue culture platform that allows co-culture of spheroids, organoids, and tumors with a perfused microvascular bed and vascularization of 3D tissues.
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OrganoStart Packages
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Start today with 3D tissue modeling
Kickstart your first experiments with the OrganoPlate® through our OrganoStart packages.
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OrganoReady®
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OrganoReady® Organoid
Offering 40 or 64 ready-to-use ASC-derived organoid tubules for drug exposure, transport, and permeability studies.
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OrganoReady® Collagen
Offering 40 or 64 ready-to-use chips pre-seeded with Collagen-I for faster, and more flexible workflow.
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OrganoReady® Colon Caco-2
Offering 40 or 64 ready-to-use Caco-2 tubules to assess gut permeability, compound toxicity, and transport.
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OrganoReady® Blood-Brain Barrier HBMEC
Offering 40 or 64 ready-to-use HBMEC tubules to quantify blood-brain barrier permeability, compound toxicity, and transport.
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OrganoReady® Blood Vessel HUVEC
Offering 40 or 64 ready-to-use HUVEC tubules to quantify vascular toxicity, compound transport, and immune migration.
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OrganoReady® Angiogenesis HUVEC
Offering 40 or 64 ready-to-sprout HUVEC tubules to quantify compound toxicity, and pro- or anti-angiogenic activity. -
OrganoReady® Vascular Bed HUVEC
Offering 64 ready-to-use HUVEC vascular beds for your vascularization studies.
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Instruments
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OrganoFlow®
Driving precisely-controlled perfusion flow in the OrganoPlate® platform
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OrganoTEER®
Enabling fast, automated, and impedance-based TEER measurements in OrganoPlate®. Assay 40 or 64 tissue culture chips with a few clicks, in less than two minutes.
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Workshops & Trainings
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Start today with 3D tissue modeling
Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
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All Products
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OrganoPlate® is the solution for all in vitro tissue culture applications. Explore the entire OrganoPlate® family and its dedicated instruments here.
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Request a quote
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Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.
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Applications
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Perfused Tubules
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Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.
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Cell-Cell Interactions
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Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.
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3D Cell Migration
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Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.
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Angiogenesis
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Membrane-free microvascular formation and growth through an extracellular matrix (ECM).
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Vascularization
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The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.
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All Applications
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OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.
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Resources & Support
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Knowledge Center
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Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.
Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.
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Publications
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Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.
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Case Studies
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Get inspired by research done by our scientists, partners, and customers around the globe.
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Blogs
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Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
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Workshops & Trainings
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Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
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Technical Support
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Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.
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Request a quote
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Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.
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FAQ
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Frequently asked questions answered by our experts. Find here the answer you're looking for.
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Knowledge Center
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About Mimetas
Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Enabling you to study cell interactions, permeability, absorption, transport, and transcytosis
Why perfused tubules?
Permeability plays a pivotal role in drug research and development. It is one of the critical factors in the absorption, distribution, metabolism, and excretion (ADME) properties of drugs and their metabolites. To adequately predict ADME/PK and toxicity of your new compounds, it is key to understand their permeability in human tissues better.
We have optimized the OrganoPlate® platform for growing perfused tubules and assessing barrier function. In OrganoPlate®, you can grow tubules at almost any complexity: from epithelial monocultures to sophisticated co-cultures, including immune cells, blood vessels, and stromal tissue. This enables you to study drug adsorption, the loss of barrier function due to drug-induced toxicity, and the permeability of compounds in the intestine, kidney, retina, lung, skin, blood-brain barrier, and blood vessels.
Features
- Polarized tubular tissues against an extracellular matrix (ECM)
- Easy apical and basolateral access
- Perfusion of the tubules mimicking shear stress
- No artificial membranes
Assays
- Fluorescent barrier integrity assay
- Transepithelial/endothelial electrical resistance (OrganoTEER®)
- Expression of junctional markers (immunostaining)
- Expression of transporters (RNA isolation and PCR, or immunostaining)
- Transport assays, imaging or sampling-based
How to grow your 3D tissue models?
Discover with this video how to grow and study your sophisticated three-dimensional (3D) tissue models in the OrganoPlate® platform.
Learn more about:
- the look and feel of OrganoPlate®
- how to the platform fits into your current workflow
- which tissue culture possibilities are of your interest
Want to know more?
Get up to speed with 3D tissue culture and learn how OrganoPlate® supports your research needs.
