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  • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
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Perfused Tubules

Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Enabling you to study cell interactions, permeability, absorption, transport, and transcytosis
without physical barriers.

Why perfused tubules?

Permeability plays a pivotal role in drug research and development. It is one of the critical factors in the absorption, distribution, metabolism, and excretion (ADME) properties of drugs and their metabolites. To adequately predict ADME/PK and toxicity of your new compounds, it is key to understand their permeability in human tissues better.

We have optimized the OrganoPlate® platform for growing perfused tubules and assessing barrier function. In OrganoPlate®, you can grow tubules at almost any complexity: from epithelial monocultures to sophisticated co-cultures, including immune cells, blood vessels, and stromal tissue. This enables you to study drug adsorption, the loss of barrier function due to drug-induced toxicity, and the permeability of compounds in the intestine, kidney, retina, lung, skin, blood-brain barrier, and blood vessels.

All Applications

Features

  • Polarized tubular tissues against an extracellular matrix (ECM)
  • Easy apical and basolateral access
  • Perfusion of the tubules mimicking shear stress
  • No artificial membranes

 

Assays

  • Fluorescent barrier integrity assay
  • Transepithelial/endothelial electrical resistance (OrganoTEER®)
  • Expression of junctional markers (immunostaining)
  • Expression of transporters (RNA isolation and PCR, or immunostaining)
  • Transport assays, imaging or sampling-based

How to grow your 3D tissue models?

Discover with this video how to grow and study your sophisticated three-dimensional (3D) tissue models in the OrganoPlate® platform.

Learn more about:

  • the look and feel of OrganoPlate®
  • how to the platform fits into your current workflow
  • which tissue culture possibilities are of your interest

Our Technology

 

Related

Publications

More Publications

Products

 

Product Overview

Get inspired

eBook
Building 3D in vitro intestinal permeability models for drug development

Case Study
Intestinal Model for IBD in collaboration with PMI

Webinar
Tissue Barriers: Expanding Your Possibilities

App Note
Comparison of the OrganoPlate® and the Transwell® platform for in vitro Intestinal Permeability Assays

Infographic
Methods to Assess Barrier Integrity & Permeability in 3D Tissue Models

Want to know more?


Get up to speed with 3D tissue culture and learn how OrganoPlate® supports your research needs.

Knowledge Center Contact us

What customers say
'
Our exciting collaboration enables our research and early development group to apply state-of-the-art organ-on-a-chip technology in the modeling of IBD and HBV. These models have the potential to improve our understanding of disease biology and transform

James Sabry, Global Head
Roche Pharma Partnering

What customers say
'
"The OrganoReady Colon Caco-2, combined with the OrganoTEER, have become our gold standard in vitro model for the screening of intestinal barrier disruptors at SIAF. "

Cezmi Akdis
Director SIAF
University Zurich

What customers say
'
The OrganoPlate Caco-2 model is for us, at Merck, the most suitable platform offering at the same time scalability, speed, robustness, ease of handling, with low compound needs.

Philip Hewitt
Head of Early Investigative Toxicology
Merck KGaA

The 'I' in MIMETAS
Chiwan Chiang
Field Application Specialist
'
A day without
laughter is a day wasted.
Read more
What customers say
'
Mimetas' tumor infiltration platform demonstrated a therapeutic effect of our compound on immune cell recruitment: we’re very excited by these proof of concept data

Scientist
From a top pharma

The 'I' in MIMETAS
Jos Joore
CEO
'
We want to
empower research on complex tissue biology.
Read more
What customers say
'
Often you have to compromise it’s either the throughput or it’s the complexity of the model. Getting both in the same platform… no other platform can do that!

Scientist
From a top pharma

The 'I' in MIMETAS
Nienke Wevers
Senior Scientist
'
Nothing ventured, nothing gained.
Read more
What customers say
'
We were able to measure cell barrier permeabilities in a lung-on-a-chip model demonstrating superior sensitivity and translatability than any other lung cell model we tried before. It was also very easy to scale up our data generation workflow.

Scientist
From a top commercial organization

The 'I' in MIMETAS
Henriëtte Lanz
Director of Model Development
'
It should be
mandatory to
socialize with colleagues.
Read more
What customers say
'
Organoplates opened avenues that were before considered unreachable

Laura Perin, PhD
Children’s Hospital Los Angeles

The 'I' in MIMETAS
Bas Trietsch
Chief Technology Officer
'
We try to help
each other
as a team.
Read more
What customers say
'
The OrganoReady model has been very useful for fast screening of novel gene therapy related technologies in our company. The membrane-free fluidics is a high throughput screening tool to monitor a transfer of antibodies through the blood brain barrier.

Svetlana Pasteuning
VectorY B.V., Netherlands

The 'I' in MIMETAS
Jacquelien Ten Dam
Chief Financial Officer
'
It always seems impossible until it’s done.
Read more
The 'I' in MIMETAS
Paul Vulto
CEO
'
Leveraging who you are, is the key to making a difference!
Read more
The 'I' in MIMETAS
Tina Thakkar
Associate Director of Sales
'
It is not really
work if you are
having fun.
Read more
The 'I' in MIMETAS
Liis Rannamäe
Laboratory Technician
'
Can be summarized in three words - engaging, playful, and innovative.
Read more
The 'I' in MIMETAS
Mieke Doornbos
Vice President Sales & Marketing
'
Celebrate
good times.
Read more
The 'I' in MIMETAS
Frederik Schavemaker
Product Design Engineer
'
Pioneering, bringing the best solutions
for scientific
discovery.
Read more
The 'I' in Mimetas
Remko van Vught
Vice President Business Development
'
Making
a difference
together.
Read more
The 'I' in MIMETAS
Lenie van den Broek
Director Biology Discovery
'
Dynamic and innovative - each day holds a surprise.
Read more
Expert Oncology Discussion
'
New Roundtable Discussion



Therapeutic Developments and Innovative Strategies in Oncology: An Expert Discussion
Watch it here

Press Release
'
MIMETAS and Astellas Enter into Strategic Partnership on Immuno-oncology

The partnership comprises utilizing MIMETAS’ comprehensive tumor models to support the next generation of immuno-oncological therapies.

Read the full article here

Grow.Learn.Discover. Event
'
A Decade of Breakthroughs in Human Tissue Modeling

Looking back at a Celebration of a Decade of Breakthroughs from our online anniversary event this past February, 9th, 2023.

Access the on-demand recordings here

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