-
Drug Discovery
-
Preclinical Research
-
Collaborate With Us
-
Resources & Support
-
Publications
-
Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.
-
-
Blogs
-
Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
-
-
Case Studies
-
Get inspired by research done by our scientists, partners, and customers around the globe.
-
-
Webinars & Events
-
Applications
-
-
About Mimetas
-
About us
-
Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
-
-
Contact us
-
Locations
-
Careers
-
-
News
Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Enabling you to study cell interactions, permeability, absorption, transport, and transcytosis
Why perfused tubules?
Permeability plays a pivotal role in drug research and development. It is one of the critical factors in the absorption, distribution, metabolism, and excretion (ADME) properties of drugs and their metabolites. To adequately predict ADME/PK and toxicity of your new compounds, it is key to understand their permeability in human tissues better.
We have optimized the OrganoPlate® platform for growing perfused tubules and assessing barrier function. In OrganoPlate®, you can grow tubules at almost any complexity: from epithelial monocultures to sophisticated co-cultures, including immune cells, blood vessels, and stromal tissue. This enables you to study drug adsorption, the loss of barrier function due to drug-induced toxicity, and the permeability of compounds in the intestine, kidney, retina, lung, skin, blood-brain barrier, and blood vessels.
Features
- Polarized tubular tissues against an extracellular matrix (ECM)
- Easy apical and basolateral access
- Perfusion of the tubules mimicking shear stress
- No artificial membranes
Assays
- Fluorescent barrier integrity assay
- Transepithelial/endothelial electrical resistance (OrganoTEER®)
- Expression of junctional markers (immunostaining)
- Expression of transporters (RNA isolation and PCR, or immunostaining)
- Transport assays, imaging or sampling-based
How to grow your 3D tissue models?
Discover with this video how to grow and study your sophisticated three-dimensional (3D) tissue models in the OrganoPlate® platform.
Learn more about:
- the look and feel of OrganoPlate®
- how to the platform fits into your current workflow
- which tissue culture possibilities are of your interest
Want to know more?
Get up to speed with 3D tissue culture and learn how OrganoPlate® supports your research needs.
Celebrate good times.
Mieke Doornbos
Vice President
Sales & Marketing
Vice President
Sales & Marketing
Our exciting collaboration enables our research and early development group to apply state-of-the-art organ-on-a-chip technology in the modeling of IBD and HBV. These models have the potential to improve our understanding of disease biology and transform
James Sabry, Global Head
Roche Pharma Partnering
"The OrganoReady Colon Caco-2, combined with the OrganoTEER, have become our gold standard in vitro model for the screening of intestinal barrier disruptors at SIAF. "
Cezmi Akdis
Director SIAF
University Zurich
The OrganoPlate Caco-2 model is for us, at Merck, the most suitable platform offering at the same time scalability, speed, robustness, ease of handling, with low compound needs.
Philip Hewitt
Head of Early Investigative Toxicology
Merck KGaA
Chiwan Chiang
Field Application Specialist
A day without
laughter is a day wasted.
laughter is a day wasted.
Pioneering to the best solutions for scientific discovery.
Frederik Schavemaker
Product Design Engineer
Product Design Engineer
Mimetas' tumor infiltration platform demonstrated a therapeutic effect of our compound on immune cell recruitment: we’re very excited by these proof of concept data
Scientist
From a top pharma
Jos Joore
CEO
We want to
empower research on complex tissue biology.
empower research on complex tissue biology.
Engaging, playful and innovative.
Liis Rannamae
Technician
Technician
Often you have to compromise it’s either the throughput or it’s the complexity of the model. Getting both in the same platform… no other platform can do that!
Scientist
From a top pharma
Nienke Wevers
Senior Scientist
Nothing ventured, nothing gained.
We were able to measure cell barrier permeabilities in a lung-on-a-chip model demonstrating superior sensitivity and translatability than any other lung cell model we tried before. It was also very easy to scale up our data generation workflow.
Scientist
From a top commercial organization
Henriëtte Lanz
Director of Model Development
It should be
mandatory to
socialize with colleagues.
mandatory to
socialize with colleagues.
Organoplates opened avenues that were before considered unreachable
Laura Perin, PhD
Children’s Hospital Los Angeles
Bas Trietsch
Chief Technology Officer
We try to help
each other
as a team.
each other
as a team.
The OrganoReady model has been very useful for fast screening of novel gene therapy related technologies in our company. The membrane-free fluidics is a high throughput screening tool to monitor a transfer of antibodies through the blood brain barrier.
Svetlana Pasteuning
VectorY B.V., Netherlands
Jacquelien Ten Dam
Chief Financial Officer
It always seems impossible until it’s done.
Paul Vulto
CEO
Leveraging who you are, is the key to making a difference!
Tina Thakkar
Associate Director of Sales
It is not really work if you are having fun.
Liis Rannamäe
Laboratory Technician
Can be summarized in three words - engaging, playful, and innovative.
