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  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
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Perfused Tubules

Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Enabling you to study cell interactions, permeability, absorption, transport, and transcytosis
without physical barriers.

Why perfused tubules?

Permeability plays a pivotal role in drug research and development. It is one of the critical factors in the absorption, distribution, metabolism, and excretion (ADME) properties of drugs and their metabolites. To adequately predict ADME/PK and toxicity of your new compounds, it is key to understand their permeability in human tissues better.

We have optimized the OrganoPlate® platform for growing perfused tubules and assessing barrier function. In OrganoPlate®, you can grow tubules at almost any complexity: from epithelial monocultures to sophisticated co-cultures, including immune cells, blood vessels, and stromal tissue. This enables you to study drug adsorption, the loss of barrier function due to drug-induced toxicity, and the permeability of compounds in the intestine, kidney, retina, lung, skin, blood-brain barrier, and blood vessels.

All Applications


  • Polarized tubular tissues against an extracellular matrix (ECM)
  • Easy apical and basolateral access
  • Perfusion of the tubules mimicking shear stress
  • No artificial membranes



  • Fluorescent barrier integrity assay
  • Transepithelial/endothelial electrical resistance (OrganoTEER®)
  • Expression of junctional markers (immunostaining)
  • Expression of transporters (RNA isolation and PCR, or immunostaining)
  • Transport assays, imaging or sampling-based

How to grow your 3D tissue models?

Discover with this video how to grow and study your sophisticated three-dimensional (3D) tissue models in the OrganoPlate® platform.

Learn more about:

  • the look and feel of OrganoPlate®
  • how to the platform fits into your current workflow
  • which tissue culture possibilities are of your interest

Our Technology


Want to know more?

Get up to speed with 3D tissue culture and learn how OrganoPlate® supports your research needs.

Knowledge Center Contact us


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