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PhaseGuide™ technology
Membrane-free tissue culture
OrganoPlate® employs a unique patented liquid handling technology, called Phaseguides™. Phaseguides™ are meticulously designed meniscus pinning barriers. They enable precise, barrier-free definition of culture matrices and cells in 3D, supporting cell-cell interactions and unprecedented imaging and quantification. OrganoPlate is versatile, supporting chemical gradients of chemical compounds and proteins and co-culture conditions. Enabling you to develop (complex) tissue models straightforwardly.
Perfusion without pumps and tubing
Continuous media perfusion through the microfluidic networks in the OrganoPlate mimics blood flow and enables the exchange of nutrients, oxygen, and metabolites. The unique gravity-driven leveling technology maintains flow without pumps and tubing, making the OrganoPlate suitable for any throughput. The OrganoFlow® provides continuous medium flow in the OrganoPlate with minimal settings required.
About the OrganoPlate
Compatible & automatable
SBS-standard 384-well OrganoPlate® format, compatible with automated imaging and robotic liquid handling equipment.
Medium perfusion, pump-free
Effortless continuous medium flow for metabolic homeostasis, compound delivery & sampling, interstitial flow, and exposure to shear stress.
Co-culture, membrane-free
Layered tissues without artificial membranes with perfect imaging, for studying barrier-free cell interactions, migration, invasion, transport, and angiogenesis.
Excellent (3D) imaging
High-quality optical materials with fixed tissue dimensions in a single horizontal plane for automated fluorescent, confocal, and standard light microscopy
Applications
Cost-effective & comprehensive ecosystem
- Fit-for-purpose
- Several versatile microfluidic designs
- Requires the lowest investments in dedicated equipment possible
- Suitable for developing just a few human tissues to a full-blown phenotypic screen
Broad assay compatibility
Immunostaining, barrier integrity, TEER, transport, viability, off-plate assays like LC-MS, qPCR, sequencing, and many more. All requiring only minimal adjustments to existing protocols in your (confocal) microscope, high-content reader, and other standard equipment.
Low compound absorption
Only low-absorbing materials are used in the OrganoPlate®, no PDMS. This enables full control of compound concentrations in your assays.
OrganoPlate® family
OrganoPlate® is the solution for all in vitro tissue culture applications. With several versatile microfluidic designs and dedicated instruments, it enables unique novel tissue culture applications.
Explore the OrganoPlate® family and find out which design supports your research needs.
Want to know more?
Get up to speed with 3D tissue culture and learn how OrganoPlate® supports your research needs.
