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Technology
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Services
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Drug Development Partnerships
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Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
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Custom Model & Assay Development
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We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
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Compound profiling & Screening
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Get robust compound data in human tissue models through our services. With proven phenotypic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
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All Services
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We offer several services to support your drug discovery and development needs. Find the overview here.
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Products
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OrganoPlate®
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OrganoPlate® 2-lane 96
Supporting up to 96 tissue models on a single plate.
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OrganoPlate® 3-lane 40
Supporting up to 40 tissue models on a single plate.
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OrganoPlate® 3-lane 64
Supporting up to 64 tissue models on a single plate.
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OrganoPlate® Graft
The first in vitro tissue culture platform that allows co-culture of spheroids, organoids, and tumors with a perfused microvascular bed and vascularization of 3D tissues.
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OrganoStart Packages
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Start today with 3D tissue modeling
Kickstart your first experiments with the OrganoPlate® through our OrganoStart packages.
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OrganoReady®
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OrganoReady® Organoid
Offering 64 ready-to-use ASC-derived organoid tubules for drug exposure, transport, and permeability studies.
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OrganoReady® Collagen
Offering 40 or 64 ready-to-use chips pre-seeded with Collagen-I for faster, and more flexible workflow.
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OrganoReady® Colon Caco-2
Offering 40 or 64 ready-to-use Caco-2 tubules to assess gut permeability, compound toxicity, and transport.
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OrganoReady® Blood-Brain Barrier HBMEC
Offering 40 or 64 ready-to-use HBMEC tubules to quantify blood-brain barrier permeability, compound toxicity, and transport.
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OrganoReady® Blood Vessel HUVEC
Offering 40 or 64 ready-to-use HUVEC tubules to quantify vascular toxicity, compound transport, and immune migration.
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OrganoReady® Angiogenesis HUVEC
Offering 64 ready-to-sprout HUVEC tubules to quantify compound toxicity, and pro- or anti-angiogenic activity. -
OrganoReady® Vascular Bed HUVEC
Offering 64 ready-to-use HUVEC vascular beds for your vascularization studies.
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Instruments
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OrganoFlow®
Driving precisely-controlled perfusion flow in the OrganoPlate® platform
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OrganoTEER®
Enabling fast, automated, and impedance-based TEER measurements in OrganoPlate®. Assay 40 or 64 tissue culture chips with a few clicks, in less than two minutes.
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Workshops & Trainings
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Start today with 3D tissue modeling
Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
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All Products
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OrganoPlate® is the solution for all in vitro tissue culture applications. Explore the entire OrganoPlate® family and its dedicated instruments here.
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Request a quote
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Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.
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Applications
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Perfused Tubules
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Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.
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Cell-Cell Interactions
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Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.
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3D Cell Migration
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Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.
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Angiogenesis
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Membrane-free microvascular formation and growth through an extracellular matrix (ECM).
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Vascularization
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The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.
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All Applications
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OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.
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Resources & Support
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Knowledge Center
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Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.
Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.
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Publications
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Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.
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Case Studies
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Get inspired by research done by our scientists, partners, and customers around the globe.
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Blogs
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Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
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Workshops & Trainings
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Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
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Technical Support
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Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.
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Request a quote
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Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.
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FAQ
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Frequently asked questions answered by our experts. Find here the answer you're looking for.
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Knowledge Center
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About Mimetas
PhaseGuide™ technology
Membrane-free tissue culture
OrganoPlate® employs a unique patented liquid handling technology, called Phaseguides™. Phaseguides™ are meticulously designed meniscus pinning barriers. They enable precise, barrier-free definition of culture matrices and cells in 3D, supporting cell-cell interactions and unprecedented imaging and quantification. OrganoPlate is versatile, supporting chemical gradients of chemical compounds and proteins and co-culture conditions. Enabling you to develop (complex) tissue models straightforwardly.
Perfusion without pumps and tubing
Continuous media perfusion through the microfluidic networks in the OrganoPlate mimics blood flow and enables the exchange of nutrients, oxygen, and metabolites. The unique gravity-driven leveling technology maintains flow without pumps and tubing, making the OrganoPlate suitable for any throughput. The OrganoFlow® provides continuous medium flow in the OrganoPlate with minimal settings required.
About the OrganoPlate
Compatible & automatable
SBS-standard 384-well OrganoPlate® format, compatible with automated imaging and robotic liquid handling equipment.
Medium perfusion, pump-free
Effortless continuous medium flow for metabolic homeostasis, compound delivery & sampling, interstitial flow, and exposure to shear stress.
Co-culture, membrane-free
Layered tissues without artificial membranes with perfect imaging, for studying barrier-free cell interactions, migration, invasion, transport, and angiogenesis.
Excellent (3D) imaging
High-quality optical materials with fixed tissue dimensions in a single horizontal plane for automated fluorescent, confocal, and standard light microscopy
Applications
Cost-effective & comprehensive ecosystem
- Fit-for-purpose
- Several versatile microfluidic designs
- Requires the lowest investments in dedicated equipment possible
- Suitable for developing just a few human tissues to a full-blown phenotypic screen
Broad assay compatibility
Immunostaining, barrier integrity, TEER, transport, viability, off-plate assays like LC-MS, qPCR, sequencing, and many more. All requiring only minimal adjustments to existing protocols in your (confocal) microscope, high-content reader, and other standard equipment.
Low compound absorption
Only low-absorbing materials are used in the OrganoPlate®, no PDMS. This enables full control of compound concentrations in your assays.
OrganoPlate® family
OrganoPlate® is the solution for all in vitro tissue culture applications. With several versatile microfluidic designs and dedicated instruments, it enables unique novel tissue culture applications.
Explore the OrganoPlate® family and find out which design supports your research needs.
Want to know more?
Get up to speed with 3D tissue culture and learn how OrganoPlate® supports your research needs.
