Technology
Services
- Drug Development Partnerships
  Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate^® platform. Together we make the therapeutics of tomorrow.
- Custom Model & Assay Development
  We create novel human tissue and disease models in the OrganoPlate^® platform. Our experts are looking forward to developing assays according to your specifications.
- Compound profiling & Screening
  Get robust compound data in human tissue models through our services. With proven phenotypic assays in the OrganoPlate^® platform, we support your drug discovery and development needs.
- All Services
  We offer several services to support your drug discovery and development needs. Find the overview here.
Products
- OrganoPlate^®
  OrganoPlate^® 2-lane 96
  Supporting up to 96 tissue models on a single plate.
  
  OrganoPlate^® 3-lane 40
  Supporting up to 40 tissue models on a single plate.
  
  OrganoPlate^® 3-lane 64
  Supporting up to 64 tissue models on a single plate.
  
  OrganoPlate^® Graft
  The first in vitro tissue culture platform that allows co-culture of spheroids, organoids, and tumors with a perfused microvascular bed and vascularization of 3D tissues.
- OrganoStart Packages
  Start today with 3D tissue modeling
  Kickstart your first experiments with the OrganoPlate^® through our OrganoStart packages.
- OrganoReady^®
  OrganoReady^®Organoid
  Offering 40 or 64 ready-to-use ASC-derived organoid tubules for drug exposure, transport, and permeability studies.
  
  OrganoReady^® Collagen
  Offering 40 or 64 ready-to-use chips pre-seeded with Collagen-I for faster, and more flexible workflow.
  
  OrganoReady^® Colon Caco-2
  Offering 40 or 64 ready-to-use Caco-2 tubules to assess gut permeability, compound toxicity, and transport.
  
  OrganoReady^® Blood-Brain Barrier HBMEC
  
  Offering 40 or 64 ready-to-use HBMEC tubules to quantify blood-brain barrier permeability, compound toxicity, and transport.
  
  OrganoReady^® Blood Vessel HUVEC
  Offering 40 or 64 ready-to-use HUVEC tubules to quantify vascular toxicity, compound transport, and immune migration.
  
  OrganoReady^®Angiogenesis HUVEC
  Offering 40 or 64 ready-to-sprout HUVEC tubules to quantify compound toxicity, and pro- or anti-angiogenic activity.
  
  OrganoReady^® Vascular Bed HUVEC
  Offering 64 ready-to-use HUVEC vascular beds for your vascularization studies.
- Instruments
  OrganoFlow^®
  Driving precisely-controlled perfusion flow in the OrganoPlate^® platform
  
  OrganoTEER^®
  Enabling fast, automated, and impedance-based TEER measurements in OrganoPlate^®. Assay 40 or 64 tissue culture chips with a few clicks, in less than two minutes.
- Workshops & Trainings
  Start today with 3D tissue modeling
  Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
- All Products
  OrganoPlate^® is the solution for all in vitro tissue culture applications. Explore the entire OrganoPlate^® family and its dedicated instruments here.
- Request a quote
  Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.
Applications
- Perfused Tubules
  Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.
- Cell-Cell Interactions
  Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.
- 3D Cell Migration
  Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.
- Angiogenesis
  Membrane-free microvascular formation and growth through an extracellular matrix (ECM).
- Vascularization
  The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate^® Graft.
- All Applications
  OrganoPlate^® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.
Resources & Support
- Knowledge Center
  Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate^® supports your research needs.
  
  Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.
- Publications
  Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.
- Case Studies
  Get inspired by research done by our scientists, partners, and customers around the globe.
- Blogs
  Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
- Workshops & Trainings
  Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
- Technical Support
  Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.
- Request a quote
  Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.
- FAQ
  Frequently asked questions answered by our experts. Find here the answer you're looking for.
Knowledge Center
About Mimetas
- Company
  Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
- Contact
- Locations
- News
- Events
- Careers

Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate^® platform. Together we make the therapeutics of tomorrow.

We create novel human tissue and disease models in the OrganoPlate^® platform. Our experts are looking forward to developing assays according to your specifications.

Get robust compound data in human tissue models through our services. With proven phenotypic assays in the OrganoPlate^® platform, we support your drug discovery and development needs.

We offer several services to support your drug discovery and development needs. Find the overview here.

OrganoPlate^® 2-lane 96
Supporting up to 96 tissue models on a single plate.
OrganoPlate^® 3-lane 40
Supporting up to 40 tissue models on a single plate.
OrganoPlate^® 3-lane 64
Supporting up to 64 tissue models on a single plate.
OrganoPlate^® Graft
The first in vitro tissue culture platform that allows co-culture of spheroids, organoids, and tumors with a perfused microvascular bed and vascularization of 3D tissues.

Start today with 3D tissue modeling
Kickstart your first experiments with the OrganoPlate^® through our OrganoStart packages.

OrganoReady^®Organoid
Offering 40 or 64 ready-to-use ASC-derived organoid tubules for drug exposure, transport, and permeability studies.
OrganoReady^® Collagen
Offering 40 or 64 ready-to-use chips pre-seeded with Collagen-I for faster, and more flexible workflow.
OrganoReady^® Colon Caco-2
Offering 40 or 64 ready-to-use Caco-2 tubules to assess gut permeability, compound toxicity, and transport.
OrganoReady^® Blood-Brain Barrier HBMEC

Offering 40 or 64 ready-to-use HBMEC tubules to quantify blood-brain barrier permeability, compound toxicity, and transport.
OrganoReady^® Blood Vessel HUVEC
Offering 40 or 64 ready-to-use HUVEC tubules to quantify vascular toxicity, compound transport, and immune migration.
OrganoReady^®Angiogenesis HUVEC
Offering 40 or 64 ready-to-sprout HUVEC tubules to quantify compound toxicity, and pro- or anti-angiogenic activity.
OrganoReady^® Vascular Bed HUVEC
Offering 64 ready-to-use HUVEC vascular beds for your vascularization studies.

OrganoFlow^®
Driving precisely-controlled perfusion flow in the OrganoPlate^® platform
OrganoTEER^®
Enabling fast, automated, and impedance-based TEER measurements in OrganoPlate^®. Assay 40 or 64 tissue culture chips with a few clicks, in less than two minutes.

Start today with 3D tissue modeling
Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.

OrganoPlate^® is the solution for all in vitro tissue culture applications. Explore the entire OrganoPlate^® family and its dedicated instruments here.

Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.

Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.

Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate^® Graft.

OrganoPlate^® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate^® supports your research needs.

Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.

Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

Get inspired by research done by our scientists, partners, and customers around the globe.

Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.

Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.

Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.

Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

Frequently asked questions answered by our experts. Find here the answer you're looking for.

Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.

Inflammatory Bowel Disease (IBD)

The challenges of IBD drug development

Intestinal inflammation is among the most prevalent health indications in the western world, comprising a range of diseases, including inflammatory bowel disease (IBD). Efficient treatments for IBD, however, are lacking.

Unfortunately, the exact mechanisms behind IBD are poorly understood owing to its multifactorial etiology; Studying such an intricate disease successfully can never be achieved with a simple culture system.

The complexity of the disease, combined with the lack of suitable models makes studying IBD and the development of preventative or therapeutic agents challenging.

Drug Development Partnerships

Watch our Roundtable Discussion on IBD

Drug development partnerships to find novel IBD therapeutics

Why a 3D IBD model?

There is an urgent need for physiologically relevant intestinal in vitro culture systems with modular biological complexity.

Existing models for IBD and the gastrointestinal system are often a compromise between biological relevance and scalability
Simple 2D models fail to recapitulate the key aspects of the intestine and of the compromised immune system. Animal models have limited translatability.
In addition, different phases of drug development demand varying complexity and screenability of the cell culture model.

With our ground-breaking 3D human tissue disease models and expertise, we bring disease-relevance and human complexity to the root of IBD drug development.

Our partnership with Roche

Together with Roche, we recently started a partnership to develop human disease models to characterize novel compounds in inflammatory bowel disease (IBD).

We will be responsible for developing tissue-based disease models and assays in the OrganoPlate® , our proprietary organ-on-a-chip platform that increases the predictability of biomarkers and reduces animal use in scientific testing. Roche will gain access to technology, disease models, and scientific results.

Our collaboration