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  • Technology
  • Products
    • OrganoPlate® 2-lane 96
      • Supporting up to 96 tissue models on a single plate. Its unique PhaseGuide™ technology enables cells to interact and migrate freely between the two channels of each chip.

    • OrganoPlate® 3-lane 40
      • Supporting up to 40 tissue models on a single plate. Its unique PhaseGuide™ technology enables cells to interact and migrate freely between the three channels of each chip.
    • OrganoPlate® 3-lane 64
      • Supporting up to 64 tissue models on a single plate. Specially designed for automated workflows. Its unique PhaseGuide™ technology enables cells to interact and migrate freely between the three channels of each chip.
    • OrganoPlate® Graft
      • The first in vitro tissue culture platform that allows co-culture of spheroids, organoids, and tumors with a perfused microvascular bed and vascularization of 3D tissues.

    • OrganoReady® Caco-2
      • Offering 38 ready-to-use Caco-2 tubules for drug exposure, transport, and permeability studies.
    • OrganoFlow®
      • Driving precisely-controlled perfusion flow in the OrganoPlate® platform
    • OrganoTEER®
      • Enabling fast, automated, and impedance-based TEER measurements in OrganoPlate®. Assay 40 tissue culture chips with a few clicks, in less than one minute.
    • Workshops & Trainings
      • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
    • All Products
      • OrganoPlate® is the solution for all in vitro tissue culture applications. Explore the entire OrganoPlate® family and its dedicated instruments here.

    • Request a quote
      • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Services
    • Compound profiling & Screening
      • Get robust compound data in human tissue models through our OrganoServices. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
    • Custom Model & Assay Development
      • We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
    • Drug Development Partnerships
      • Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
    • All Services
      • We offer several services to support your drug discovery and development needs. Find the overview here.
  • Applications
    • Perfused Tubules
      • Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.

    • Cell-Cell Interactions
      • Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

    • 3D Cell Migration
      • Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.

    • Angiogenesis
      • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

    • Vascularization
      • The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.

    • All Applications
      • OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

  • Resources & Support
    • Knowledge Center
      • Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.

        Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.

    • Publications
      • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

    • Case Studies
      • Get inspired by research done by our scientists, partners, and customers around the globe.

    • Blogs
      • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
    • Workshops & Trainings
      • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
    • Technical Support
      • Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.
    • Request a quote
      • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

    • FAQ
      • Frequently asked questions answered by our experts. Find here the answer you're looking for.
  • About Mimetas
  • Supporting up to 96 tissue models on a single plate. Its unique PhaseGuide™ technology enables cells to interact and migrate freely between the two channels of each chip.

  • Supporting up to 40 tissue models on a single plate. Its unique PhaseGuide™ technology enables cells to interact and migrate freely between the three channels of each chip.
  • Supporting up to 64 tissue models on a single plate. Specially designed for automated workflows. Its unique PhaseGuide™ technology enables cells to interact and migrate freely between the three channels of each chip.
  • The first in vitro tissue culture platform that allows co-culture of spheroids, organoids, and tumors with a perfused microvascular bed and vascularization of 3D tissues.

  • Offering 38 ready-to-use Caco-2 tubules for drug exposure, transport, and permeability studies.
  • Driving precisely-controlled perfusion flow in the OrganoPlate® platform
  • Enabling fast, automated, and impedance-based TEER measurements in OrganoPlate®. Assay 40 tissue culture chips with a few clicks, in less than one minute.
  • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • OrganoPlate® is the solution for all in vitro tissue culture applications. Explore the entire OrganoPlate® family and its dedicated instruments here.

  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Get robust compound data in human tissue models through our OrganoServices. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
  • We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
  • Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
  • We offer several services to support your drug discovery and development needs. Find the overview here.
  • Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.

  • Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

  • Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.

  • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

  • The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.

  • OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

  • Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.

    Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.

  • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.
  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Frequently asked questions answered by our experts. Find here the answer you're looking for.
  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
ENGLISH

Bas Trietsch

 

This interview is part of a series of conversations with the people working at Mimetas. The 'I' in Mimetas focuses on the personal side of the scientists that drive our world. Today we have a chat with Bas Trietsch, Chief Technology Officer and straight shooter at Mimetas.

How would you describe your job to me, if I were 5 years old?

At Mimetas, I work with the team to try and push the limits of our human tissue models to bring drugs to patients faster. This can involve developing new products, such new versions of the OrganoPlate, equipment or plates preloaded with biological models. It can also involve further developing how we learn from our models, for example by developing more advanced assays and applying artificial intelligence to analyse the tissues. When we find that the technology is holding back our understanding of a disease, we get to work to find new ways to more closely represent all aspects of a disease and enable better methods to understand and treat those diseases.

What does an average day for you look like working at Mimetas?

My days during the week are quite diverse. One day in the week I reserve to spend at the factory. I work with the folks in Enschede to continuously improve the quality and reliability of our products. The rest of the week I work with different teams specialized in different aspects of Mimetas. I really love working with the engineers to brainstorm om new and innovative applications of our technology. It is very satisfying to find simple and scalable solutions to the needs for complex biological models. Other days can be focused on scaling up our biological manufacturing and screening capacity. It is a blast to figure out how to combine cutting-edge biology, robot automation, high content imaging, artificial intelligence, and pharmacology and sometimes even ship it around the globe. The fact that we supply OrganoPlates and equipment, but also offer screening services and team up with pharma to discover new drugs means I get to work on all the steps of drug discovery throughout a week.

What is your favorite pastime?

Cooking! I do not only like eating and drinking good food and wine, but I also like making it. I can’t wait for summer to arrive and Covid to leave, so I can get back to enjoying a good BBQ with friends in my garden. Nothing beats beefs shortribs prepared in a drum I nicked from our factory and made into a smoker. Other than that I like traveling, snowboarding, and diving. Let’s hope those borders open up again soon!

Is it better to be perfect and late, or good and on time?

Good and on time is better. Better can be the enemy of good. I believe you only start learning about where you can really improve after you start using what you have. We are lucky to have a strong team of scientists that are always eager to try our latest innovations. Quickly iterating between engineers and biologists is what enables us to keep elevating our models. In my experience, a good product is also an elegant product. You typically don’t get there by endlessly finding a certain product, but you get there by really developing the best idea to start with. It has become a running gag in my team that our products always end up very close to our initial quick and dirty prototype. I believe this is because we have such a tight link between our end-user and engineers so that they come up with a good approach from the get-go. That’s not to say that everything always works the first try, but if it works, we are typically pretty close to what the final product will look like.

Do you prefer people being straightforward to you, or people tempering their words?

Always straightforward. I dislike it when people tip-toe around a subject, resulting in them saying “yes” when they are thinking “no”. People need to be straightforward. If I say something that is wrong, everybody in the room can call me out on it. People should be able to say what they want, which is, I think, a big strength of the Netherlands.

What small things in life make you happy?

Good coffee, going back to bed for a short nap after getting up way to early and strolling along a beach with my dog.

What is your favorite quote, song, or belief, anything that you live by?

Make the other person shine. I hate it when people try and make themselves look better by diminishing others. Instead, I think you will always shine a lot brighter if you enable everyone you work with to the best they can. I love the fact that there is very no culture at Mimetas to compete amongst ourselves, rather we try to help each other as a team. Probably one of the biggest reasons why I love every day at Mimetas, and I think I’m not the only one.