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      • Get robust compound data in human tissue models through our OrganoServices. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
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  • About Mimetas
  • Start today with 3D tissue modeling>
    Kickstart successfully your first experiments with the OrganoPlate® through our OrganoStart packages.
  • OrganoFlow® >
    Driving precisely-controlled perfusion flow in the OrganoPlate® platform

  • OrganoTEER® >
    Enabling fast, automated, and impedance-based TEER measurements in OrganoPlate®. Assay 40 tissue culture chips with a few clicks, in less than one minute.

  • Start today with 3D tissue modeling>
    Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • OrganoPlate® is the solution for all in vitro tissue culture applications. Explore the entire OrganoPlate® family and its dedicated instruments here.

  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Get robust compound data in human tissue models through our OrganoServices. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
  • We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
  • Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
  • We offer several services to support your drug discovery and development needs. Find the overview here.
  • Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.

  • Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

  • Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.

  • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

  • The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.

  • OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

  • Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.

    Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.

  • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.
  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Frequently asked questions answered by our experts. Find here the answer you're looking for.
  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
EN

eBook: Building 3D in vitro intestinal permeability models for drug development

The cost of drug development has increased rapidly over the past decades. Where the introduction of a new drug required an approximate investment of 200 million in 1970, it takes over 2 billion today.

A large portion of this cost is attributed to drug candidates that fail late in the development cycle due to unexpected toxicity or lack of efficacy. To stabilize or reverse this trend, more physiologically relevant in vitro models are required that more accurately predict clinical outcomes and thereby increase the success rate of drug development efforts.

The importance of permeability within drug development
One of the pivotal research areas in drug development is based on permeability. Permeability is one of the critical factors that contribute to the absorption, distribution, metabolism, and excretion (ADME) properties of drugs and their metabolites. Not only is it essential to study the ADME properties of a drug candidate that attributes to its efficacy, but also the toxicological effects of the drug candidate on the intestinal barrier. If the drug candidate proves toxic to the intestinal barrier and thereby increases permeability, it should be reevaluated to prevent failure at a later stage in the drug development process.

Adoption of organ-on-a-chip to mimic human physiology
Current 2D in vitro models that are used during early drug development fail to recapitulate either healthy or diseased human physiology. This hinders researchers from truly understanding the mechanisms behind diseases, such as inflammatory bowel disease, and leaves many important drug characteristics undiscovered. For this matter, the pharmaceutical industry has started the adoption of organ-on-a-chip technology. By culturing cells in 3D without the need for artificial membranes, organ-on-a-chip models closely mimic human organs in their in vivo environment. With the use of these models, researchers can deepen their understanding of disease and the effect of their drug candidates.

In this eBook, we’ve bundled various resources, compiled by our scientists, that will give you insights into why and how you can start building your intestinal permeability models in a sophisticated 3D environment. You’ll also learn why bringing back human relevance will help to accelerate drug development and its related decision-making.

Download the eBook here and join us in making human models for better therapies.

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Download the eBook here

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