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  • Start today with 3D tissue modeling>
    Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • OrganoPlate® is the solution for all in vitro tissue culture applications. Explore the entire OrganoPlate® family and its dedicated instruments here.

  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Get robust compound data in human tissue models through our OrganoServices. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
  • We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
  • Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
  • We offer several services to support your drug discovery and development needs. Find the overview here.
  • Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.

  • Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

  • Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.

  • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

  • The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.

  • OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

  • Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.

    Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.

  • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.
  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Frequently asked questions answered by our experts. Find here the answer you're looking for.
  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
EN

Case study: 3D intestine-on-a-chip model to study IBD

Investigating hallmarks of inflammatory bowel disease (IBD) in a 3D perfused multicellular intestine-on-a-chip model.

About the research

Intestinal inflammation is among the most prevalent health indications in the Western world. It comprises a range of diseases, from the less defined irritable bowel syndrome to full impairment of intestinal function in inflammatory bowel disease (IBD).

The development of preventative and therapeutic agents proved to be challenging as many of the processes involved in intestinal inflammation are still poorly understood. Reliable, robust, and high-throughput in vitro models that capture key aspects of intestinal inflammation are therefore essential for the drug development process but are still lacking. Additionally, each stage of the drug development process comes with its own specific demands in terms of complexity and screenability of the model, which further emphasizes the need for modular platforms that allow tailored biological complexity.

Custom model & assay

Together with Philip Morris International (PMI) we developed a 3D in vitro intestinal model consisting of epithelial and immune-competent cells. We demonstrated that intestinal inflammation can be induced or prevented by specific compounds, as assessed by changes in barrier function and cytokine release.

Finally, we showed how the biological complexity of the model can be adjusted, allowing us to optimize the combination of biological components relevant to intestinal inflammation and the specific research question.


Read App Note

Key results

  • An intestine-on-a-chip model of which the biological complexity can be tailored to the specific research question: plug-and-play modularity
  • Induction and prevention of intestinal inflammation
  • Suitable for studying intestinal inflammation or screening anti-inflammatory compounds

About Perfused Tubules

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