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OrganoReady® Colon Caco-2

40 or 64 ready-to-use Caco-2 tubules to assess gut permeability, compound toxicity, and transport.

Do you want to perform experiments in human-relevant, complex 3D tissue models but don’t have the time or experience to build your own? Look no further, with the OrganoReady Colon Caco-2 you can now easily take your intestinal research to the next level. Perform your self-created experiments to investigate permeability, absorption and transport, ​toxicity, and barrier integrity (TEER) in a physiologically relevant model.

OrganoReady® Colon Caco-2 features:

  • OrganoPlate® 3-lane 40 or 3-lane 64, including:
    • 40 or 64 chips with ready-to-use Caco-2 tubules
  • Direct access to the apical and basal lumen of tubules
  • Caco-2 cell line: Human Caucasian colon adenocarcinoma, Wild-Type
  • ECM: Collagen I (Rat Tail)

Each tissue culture chip contains one in-gel culture channel and two perfusion channels, of which one perfused Caco-2 tubule. Compounds and stimuli can directly be added from the apical and basolateral sides of the culture. With this direct access, the platform enables perfusion and supports various barrier function and transport assays.

Our Technology

Product details

Meet the OrganoReady Colon Caco-2


Ready-to-assay gut tubules
40 or 64 ready-to-use Caco-2 tubules, seeded against collagen I, allowing you to perform assays right away.

We create the model, so you can focus on your assays
Preparation and QC of OrganoReady Caco-2 are done by our experts. Use the OrganoReady Colon Caco-2 directly after arrival for up to 7 days.

Get inspired by a wide range of possible applications
Study for example (drug-induced) toxicity, transport, use it for disease modeling or for fundamental research on the intestinal barrier.

Apical and basal access
Perfused Caco-2 tubules, allowing barrier integrity (TEER), transporter (e.g. P-gp), and permeability assays.

No artificial membranes for free migration, invasion, and exchanges of factors
Unique PhaseGuide™ technology allows cells to interact and migrate freely between channels.





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Get inspired


Selected Publications

Find more publications here.

App Note
Comparison of the OrganoPlate® and the Transwell® Platform for In Vitro Intestinal Permeability Assays

Infographic
Why OrganoReady® Caco-2?

OrganoReady Caco-2:
how it works


The Caco-2 tubules allow for apical and basal access, enabling barrier integrity and transport assays. The model lends itself to study toxicity, transport, and disease or can be used for fundamental research on the intestinal barrier.

Here we show an example of the Caco-2 intestinal tubule grown against an extracellular matrix (ECM). The tubule shows clear lumen and the arrows indicate the apical and basal sides of the culture.

About Perfused Tubules Product Flyer

Want to know more?


Get up to speed with 3D tissue culture and learn how OrganoPlate® supports your research needs.

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Living innovation

Mimetas Anniversary - Mieke
'
Celebrate good times.
Mieke Doornbos
Vice President
Sales & Marketing
What customers say
'
Our exciting collaboration enables our research and early development group to apply state-of-the-art organ-on-a-chip technology in the modeling of IBD and HBV. These models have the potential to improve our understanding of disease biology and transform

James Sabry, Global Head
Roche Pharma Partnering

What customers say
'
"The OrganoReady Colon Caco-2, combined with the OrganoTEER, have become our gold standard in vitro model for the screening of intestinal barrier disruptors at SIAF. "

Cezmi Akdis
Director SIAF
University Zurich

What customers say
'
The OrganoPlate Caco-2 model is for us, at Merck, the most suitable platform offering at the same time scalability, speed, robustness, ease of handling, with low compound needs.

Philip Hewitt
Head of Early Investigative Toxicology
Merck KGaA

The 'I' in Mimetas
Chiwan Chiang
Field Application Specialist
'
A day without
laughter is a day wasted.
Read more
Mimetas Anniversary - Frederik
'
Pioneering to the best solutions for scientific discovery.
Frederik Schavemaker
Product Design Engineer
What customers say
'
Mimetas' tumor infiltration platform demonstrated a therapeutic effect of our compound on immune cell recruitment: we’re very excited by these proof of concept data

Scientist
From a top pharma

The 'I' in Mimetas
Jos Joore
CEO
'
We want to
empower research on complex tissue biology.
Read more
Mimetas Anniversary - Liis
'
Engaging, playful and innovative.
Liis Rannamae
Technician
What customers say
'
Often you have to compromise it’s either the throughput or it’s the complexity of the model. Getting both in the same platform… no other platform can do that!

Scientist
From a top pharma

The 'I' in Mimetas
Nienke Wevers
Senior Scientist
'
Nothing ventured, nothing gained.
Read more
What customers say
'
We were able to measure cell barrier permeabilities in a lung-on-a-chip model demonstrating superior sensitivity and translatability than any other lung cell model we tried before. It was also very easy to scale up our data generation workflow.

Scientist
From a top commercial organization

The 'I' in Mimetas
Henriëtte Lanz
Director of Model Development
'
It should be
mandatory to
socialize with colleagues.
Read more
What customers say
'
Organoplates opened avenues that were before considered unreachable

Laura Perin, PhD
Children’s Hospital Los Angeles

The 'I' in Mimetas
Bas Trietsch
Chief Technology Officer
'
We try to help
each other
as a team.
Read more
What customers say
'
The OrganoReady model has been very useful for fast screening of novel gene therapy related technologies in our company. The membrane-free fluidics is a high throughput screening tool to monitor a transfer of antibodies through the blood brain barrier.

Svetlana Pasteuning
VectorY B.V., Netherlands

The 'I' in Mimetas
Jacquelien Ten Dam
Chief Financial Officer
'
It always seems impossible until it’s done.
Read more
The 'I' in Mimetas
Paul Vulto
CEO
'
Leveraging who you are, is the key to making a difference!
Read more
The 'I' in Mimetas
Tina Thakkar
Associate Director of Sales
'
It is not really work if you are having fun.
Read more
The 'I' in Mimetas
Liis Rannamäe
Laboratory Technician
'
Can be summarized in three words - engaging, playful, and innovative.
Read more
Expert Oncology Discussion
'
New Roundtable Discussion



Therapeutic Developments and Innovative Strategies in Oncology: An Expert Discussion
Watch it here

Press Release
'
MIMETAS and Astellas Enter into Strategic Partnership on Immuno-oncology

The partnership comprises utilizing MIMETAS’ comprehensive tumor models to support the next generation of immuno-oncological therapies.

Read the full article here

Grow.Learn.Discover. Event
'
A Decade of Breakthroughs in Human Tissue Modeling

Looking back at a Celebration of a Decade of Breakthroughs from our online anniversary event this past February, 9th, 2023.

Access the on-demand recordings here

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