• We offer tailored partnerships to support and transform drug discovery.

    Every collaboration is a bespoke arrangement, meticulously designed to discover new compounds and targets in patient relevant disease models.

  • MIMETAS offers flexible fee-for-service solutions for therapy prioritization, optimization, and de-risking of compounds.

    As an extension of your team, MIMETAS provides the expertise and resources needed for effective research and development.

  • Our OrganoReady program is made for you when you need optimized assays for investigational toxicology.

    We guarantee OrganoReady performance according to specifications, in a fast and convenient sales transaction with a clear fee structure.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
open menu icon close menu icon

OrganoReady® Colon Caco-2

40 or 64 ready-to-use Caco-2 tubules to assess gut permeability, compound toxicity, and transport.

Do you want to perform experiments in human-relevant, complex 3D tissue models but don’t have the time or experience to build your own? Look no further, with the OrganoReady Colon Caco-2 you can now easily take your intestinal research to the next level. Perform your self-created experiments to investigate permeability, absorption and transport, ​toxicity, and barrier integrity (TEER) in a physiologically relevant model.

OrganoReady® Colon Caco-2 features:

  • OrganoPlate® 3-lane 40 or 3-lane 64, including:
    • 40 or 64 chips with ready-to-use Caco-2 tubules
  • Direct access to the apical and basal lumen of tubules
  • Caco-2 cell line: Human Caucasian colon adenocarcinoma, Wild-Type
  • ECM: Collagen I (Rat Tail)

Each tissue culture chip contains one in-gel culture channel and two perfusion channels, of which one perfused Caco-2 tubule. Compounds and stimuli can directly be added from the apical and basolateral sides of the culture. With this direct access, the platform enables perfusion and supports various barrier function and transport assays.

Our Technology

Product details

Meet the OrganoReady Colon Caco-2

Ready-to-assay gut tubules
40 or 64 ready-to-use Caco-2 tubules, seeded against collagen I, allowing you to perform assays right away.

We create the model, so you can focus on your assays
Preparation and QC of OrganoReady Caco-2 are done by our experts. Use the OrganoReady Colon Caco-2 directly after arrival for up to 7 days.

Get inspired by a wide range of possible applications
Study for example (drug-induced) toxicity, transport, use it for disease modeling or for fundamental research on the intestinal barrier.

Apical and basal access
Perfused Caco-2 tubules, allowing barrier integrity (TEER), transporter (e.g. P-gp), and permeability assays.

No artificial membranes for free migration, invasion, and exchanges of factors
Unique PhaseGuide™ technology allows cells to interact and migrate freely between channels.

Request QuoteStay up to date

OrganoReady Caco-2:
how it works

The Caco-2 tubules allow for apical and basal access, enabling barrier integrity and transport assays. The model lends itself to study toxicity, transport, and disease or can be used for fundamental research on the intestinal barrier.

Here we show an example of the Caco-2 intestinal tubule grown against an extracellular matrix (ECM). The tubule shows clear lumen and the arrows indicate the apical and basal sides of the culture.

About Perfused Tubules Product Flyer

Want to know more?

Get up to speed with 3D tissue culture and learn how OrganoPlate® supports your research needs.

Knowledge Center Contact us

Living innovation


May we use cookies?
Hi there! Thanks for visiting our website. We use cookies to keep track of our website statistics to optimize the user experience. We also use cookies for marketing purposes. You can set your preferences by selecting the options below. Terms of Use & Privacy Policy
Accept all
Accept selected
Decline all