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Co-culture layered & structured tissues without artificial membranes
Why cell-cell interactions?
OrganoPlate® allows you to develop a large variety of tissue- and disease models, applicable for drug testing and evaluation. Study relevant 3D tissue biology in a simple manner by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment.
We have optimized the OrganoPlate® platform to study cell-cell interaction in multiple tissue culture setups. OrganoPlate® enables you to:
- Combine a tubular culture with cells cultured in an extracellular matrix (ECM)
- Grow two tubules in parallel
- Culture two or more cell types in adjacent ECM gels
- Develop a tube-in-a-tube culture
- And more ...
Features
- Co-culture different cell types without artificial membranes
- Enable stratified co-cultures with relevant tissue structures
- Study cellular interactions, cell-cell signaling, migration
Assays
- Immunostaining for specific markers of present cell types
- Basal lamina formation
- Assess the influence of:
- supporting cells in strengthening barrier tissues
- (activated) immune cells in co-culture, for example of CNS, gut, tumor cells
- supporting cells (for example pericytes, hepatocytes) on sprouting/angiogenesis
How to grow your 3D tissue models?
Discover with this video how to grow and study your sophisticated three-dimensional (3D) tissue models in the OrganoPlate®.
Learn more about:
- the look and feel of OrganoPlate®
- how the platform fits into your current workflow
- which tissue culture possibilities are of your interest
Want to know more?
Get up to speed with 3D tissue culture and learn how OrganoPlate® supports your research needs.
Celebrate good times.
Mieke Doornbos
Vice President
Sales & Marketing
Vice President
Sales & Marketing
Our exciting collaboration enables our research and early development group to apply state-of-the-art organ-on-a-chip technology in the modeling of IBD and HBV. These models have the potential to improve our understanding of disease biology and transform
James Sabry, Global Head
Roche Pharma Partnering
"The OrganoReady Colon Caco-2, combined with the OrganoTEER, have become our gold standard in vitro model for the screening of intestinal barrier disruptors at SIAF. "
Cezmi Akdis
Director SIAF
University Zurich
The OrganoPlate Caco-2 model is for us, at Merck, the most suitable platform offering at the same time scalability, speed, robustness, ease of handling, with low compound needs.
Philip Hewitt
Head of Early Investigative Toxicology
Merck KGaA
Chiwan Chiang
Field Application Specialist
A day without
laughter is a day wasted.
laughter is a day wasted.
Pioneering to the best solutions for scientific discovery.
Frederik Schavemaker
Product Design Engineer
Product Design Engineer
Mimetas' tumor infiltration platform demonstrated a therapeutic effect of our compound on immune cell recruitment: we’re very excited by these proof of concept data
Scientist
From a top pharma
Jos Joore
CEO
We want to
empower research on complex tissue biology.
empower research on complex tissue biology.
Engaging, playful and innovative.
Liis Rannamae
Technician
Technician
Often you have to compromise it’s either the throughput or it’s the complexity of the model. Getting both in the same platform… no other platform can do that!
Scientist
From a top pharma
Nienke Wevers
Senior Scientist
Nothing ventured, nothing gained.
We were able to measure cell barrier permeabilities in a lung-on-a-chip model demonstrating superior sensitivity and translatability than any other lung cell model we tried before. It was also very easy to scale up our data generation workflow.
Scientist
From a top commercial organization
Henriëtte Lanz
Director of Model Development
It should be
mandatory to
socialize with colleagues.
mandatory to
socialize with colleagues.
Organoplates opened avenues that were before considered unreachable
Laura Perin, PhD
Children’s Hospital Los Angeles
Bas Trietsch
Chief Technology Officer
We try to help
each other
as a team.
each other
as a team.
The OrganoReady model has been very useful for fast screening of novel gene therapy related technologies in our company. The membrane-free fluidics is a high throughput screening tool to monitor a transfer of antibodies through the blood brain barrier.
Svetlana Pasteuning
VectorY B.V., Netherlands
Jacquelien Ten Dam
Chief Financial Officer
It always seems impossible until it’s done.
Paul Vulto
CEO
Leveraging who you are, is the key to making a difference!
Tina Thakkar
Associate Director of Sales
It is not really work if you are having fun.
Liis Rannamäe
Laboratory Technician
Can be summarized in three words - engaging, playful, and innovative.
