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  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
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OrganoPlate® Graft

OrganoPlate® Graft is the first in vitro tissue culture platform that allows co-culture of spheroids, organoids, and tumors with a perfused microvascular bed and vascularization of 3D tissues.

OrganoPlate® Graft features:

  • 64 independent tissue culture chips
  • 3 adjacent channels, with one open grafting chamber per chip
  • Direct access to the apical and basal lumen of tubules and vessels

Each chip contains one in-gel culture channel, two perfusion channels, and one open grafting chamber. The platform enables perfusion and addition of cells, compounds, and stimuli, and provides direct access to vascularized tissues.

Our Technology

Product details

Meet the OrganoPlate Graft


Vascularized 3D tissues
Add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments.

Flexible tissue culture configurations fitting your modeling needs
In-ECM cultures, against-ECM cultures, tubular cultures, or a combination. It’s up to you.

Apical and basal access
Enabling perfusion of tubular tissues using OrganoFlow®, allowing a wide range of biological applications, and direct access to vascularized tissues.

No artificial membranes for free migration, invasion, and exchanges of factors
Unique PhaseGuide™ technology allows cells to interact and migrate freely between channels.

Suitable for a wide range of cell types and tissue sources
Get the OrganoPlate from us, implement the cell type and/or tissue source of your choice. Multiple cell types and tissue sources possible: organoids, tissue explants, spheroids, PDX material, and more.

Multiple assays

  • In-plate: immunostaining, barrier integrity, transport, viability assays, and many more. All with tested protocols in your microscope, high content imaging microplate reader.
  • Off-plate: cytokine profiling, qPCR, LC-MS, and more.
Request Quote

Get inspired


Webinar
OrganoPlate® Graft: The Missing Link In Tissue Culture

App Note
The OrganoPlate® Graft: In Vitro Vascularization of Human Tissues

Product Flyer

 

Applications

  • Vascularization
  • Perfused tubules
  • 3D cell migration
  • Angiogenesis
  • Cell-cell interactions


All Applications

OrganoPlate® Graft:
how it works


Functional blood vessels are a vital connecting structure inside the body. This aspect is missing in all currently available in vitro cell culture techniques, until now.

OrganoPlate® Graft is developed for grafting tissues to a vascular bed. Its open-top design makes it possible to receive target tissues for studying interaction with a vascular bed. It uniquely facilitates perfusion of the tissue and allows drug administration through the vasculature. The platform can be used for vascularization studies of various tissues in areas such as oncology and toxicology.

Watch the video to learn in a nutshell how in vitro vascularization can be achieved.

About Vascularization

Want to know more?


Get up to speed with 3D tissue culture and learn how OrganoPlate® supports your research needs.

Knowledge Center Contact us

Living innovation

Mimetas Anniversary - Mieke
'
Celebrate good times.
Mieke Doornbos
Vice President
Sales & Marketing
What customers say
'
Our exciting collaboration enables our research and early development group to apply state-of-the-art organ-on-a-chip technology in the modeling of IBD and HBV. These models have the potential to improve our understanding of disease biology and transform

James Sabry, Global Head
Roche Pharma Partnering

What customers say
'
"The OrganoReady Colon Caco-2, combined with the OrganoTEER, have become our gold standard in vitro model for the screening of intestinal barrier disruptors at SIAF. "

Cezmi Akdis
Director SIAF
University Zurich

What customers say
'
The OrganoPlate Caco-2 model is for us, at Merck, the most suitable platform offering at the same time scalability, speed, robustness, ease of handling, with low compound needs.

Philip Hewitt
Head of Early Investigative Toxicology
Merck KGaA

The 'I' in Mimetas
Chiwan Chiang
Field Application Specialist
'
A day without
laughter is a day wasted.
Read more
Mimetas Anniversary - Frederik
'
Pioneering to the best solutions for scientific discovery.
Frederik Schavemaker
Product Design Engineer
What customers say
'
Mimetas' tumor infiltration platform demonstrated a therapeutic effect of our compound on immune cell recruitment: we’re very excited by these proof of concept data

Scientist
From a top pharma

The 'I' in Mimetas
Jos Joore
CEO
'
We want to
empower research on complex tissue biology.
Read more
Mimetas Anniversary - Liis
'
Engaging, playful and innovative.
Liis Rannamae
Technician
What customers say
'
Often you have to compromise it’s either the throughput or it’s the complexity of the model. Getting both in the same platform… no other platform can do that!

Scientist
From a top pharma

The 'I' in Mimetas
Nienke Wevers
Senior Scientist
'
Nothing ventured, nothing gained.
Read more
What customers say
'
We were able to measure cell barrier permeabilities in a lung-on-a-chip model demonstrating superior sensitivity and translatability than any other lung cell model we tried before. It was also very easy to scale up our data generation workflow.

Scientist
From a top commercial organization

The 'I' in Mimetas
Henriëtte Lanz
Director of Model Development
'
It should be
mandatory to
socialize with colleagues.
Read more
What customers say
'
Organoplates opened avenues that were before considered unreachable

Laura Perin, PhD
Children’s Hospital Los Angeles

The 'I' in Mimetas
Bas Trietsch
Chief Technology Officer
'
We try to help
each other
as a team.
Read more
What customers say
'
The OrganoReady model has been very useful for fast screening of novel gene therapy related technologies in our company. The membrane-free fluidics is a high throughput screening tool to monitor a transfer of antibodies through the blood brain barrier.

Svetlana Pasteuning
VectorY B.V., Netherlands

The 'I' in Mimetas
Jacquelien Ten Dam
Chief Financial Officer
'
It always seems impossible until it’s done.
Read more
The 'I' in Mimetas
Paul Vulto
CEO
'
Leveraging who you are, is the key to making a difference!
Read more
The 'I' in Mimetas
Tina Thakkar
Associate Director of Sales
'
It is not really work if you are having fun.
Read more
The 'I' in Mimetas
Liis Rannamäe
Laboratory Technician
'
Can be summarized in three words - engaging, playful, and innovative.
Read more
Expert Oncology Discussion
'
New Roundtable Discussion



Therapeutic Developments and Innovative Strategies in Oncology: An Expert Discussion
Watch it here

Press Release
'
MIMETAS and Astellas Enter into Strategic Partnership on Immuno-oncology

The partnership comprises utilizing MIMETAS’ comprehensive tumor models to support the next generation of immuno-oncological therapies.

Read the full article here

Grow.Learn.Discover. Event
'
A Decade of Breakthroughs in Human Tissue Modeling

Looking back at a Celebration of a Decade of Breakthroughs from our online anniversary event this past February, 9th, 2023.

Access the on-demand recordings here

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