• Work With Us
    • Partnerships
      • We offer tailored partnerships to support and transform drug discovery.

        Every collaboration is a bespoke arrangement, meticulously designed to discover new compounds and targets in patient relevant disease models.

    • Services
      • MIMETAS offers flexible fee-for-service solutions for therapy prioritization, optimization, and de-risking of compounds.

        As an extension of your team, MIMETAS provides the expertise and resources needed for effective research and development.

    • OrganoReady®
      • Our OrganoReady program is made for you when you need defined assays in ADME.

        We guarantee OrganoReady performance according to specifications, in a fast and convenient sales transaction with a clear fee structure.

  • Resources & Support
    • Knowledge Center
      • Get inspired by peer-reviewed publications, webinars, whitepapers, app notes and more in our knowledge center.

    • Blogs
      • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
    • Case Studies
      • Get inspired by research done by our scientists, partners, and customers around the globe.

    • Webinars & Events
    • Applications
  • About MIMETAS
  • News
  • We offer tailored partnerships to support and transform drug discovery.

    Every collaboration is a bespoke arrangement, meticulously designed to discover new compounds and targets in patient relevant disease models.

  • MIMETAS offers flexible fee-for-service solutions for therapy prioritization, optimization, and de-risking of compounds.

    As an extension of your team, MIMETAS provides the expertise and resources needed for effective research and development.

  • Our OrganoReady program is made for you when you need defined assays in ADME.

    We guarantee OrganoReady performance according to specifications, in a fast and convenient sales transaction with a clear fee structure.

  • Get inspired by peer-reviewed publications, webinars, whitepapers, app notes and more in our knowledge center.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
open menu icon close menu icon
EN

3D Cell Migration

Evaluate the effect of chemotactic triggers or cells on the migration of cells
through an extracellular matrix.

Why 3D cell migration?

Cell migration is critical in establishing and maintaining human multicellular tissues. For example, wound healing and an immune response require proper movements of cells to specific locations, while aberrant cell migration can lead to various pathologies such as metastasis and vascular diseases. Cell migration is a multi-scale and multi-disciplinary process that depends on cell signaling, chemotaxis, and cell-matrix interactions. A quantitative 3D migration model in absence of artificial membranes with a stable gradient over time is essential to understand migration behavior in human tissues better.

We have optimized the OrganoPlate® platform to perform and study 3D cell migration. The excellent imaging quality allows you to see what happens in your tissue microenvironment, provides more read-out capabilities, and improves research quality. Evaluate 3D cell migration through an extracellular matrix (ECM) and maintain a stable gradient over time. Or study the effect of compounds or triggers on the mobilization and migration of cells. It's up to you.

Features

  • Study immune, tumor, fibroblast and mesenchymal stem cell migration through an extracellular matrix
  • No obstruction by artificial membranes
  • Allows excellent imaging, cell tracing & quantification
  • Stable chemotactic gradients over time

 

Assays

  • Fluorescent barrier integrity assay
  • Monocyte adhesion assay
  • T cell migration assay
  • Immunostaining for adhesion molecules


All Applications

T cell extravasation from an endothelial vessel

OrganoPlate® allows you to perform migration studies without the obstruction of artificial membranes. Study T cell migration by growing a perfused blood vessel, adding T cells, and the trigger of interest to eventually observe migration.

This example shows T cell extravasation from an endothelial vessel into collagen ECM in OrganoPlate® 3-lane 40.

T-cell marker CD45 (red) | Actin marker (green) | Nuclei marker DAPI (blue)

Our Technology

Want to know more?


Get up to speed with 3D tissue culture and learn how OrganoPlate® supports your research needs.

Knowledge Center Contact us

Cookies

‘May we use cookies?
Hi there! Thanks for visiting our website. We use cookies to keep track of our website statistics to optimize the user experience. We also use cookies for marketing purposes. You can set your preferences by selecting the options below. Terms of Use & Privacy Policy

Accept all
Accept selected
Decline all