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  • Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
  • We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
  • Get robust compound data in human tissue models through our services. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
  • We offer several services to support your drug discovery and development needs. Find the overview here.
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  • Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.

  • Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

  • Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.

  • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

  • The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.

  • OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

  • Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.

    Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.

  • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.

  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

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EN

3D Cell migration using a Microfluidic Endothelium-on-a-Chip Model

On-demand Webinar

Cell migration is an essential process for many biological phenomena such as early embryonic development. It plays an important role in disease processes such as wound healing and cancer metastasis. The immune system, which protects us from diseases, also relies on the migration of various cell types with immensely diverse and highly specific receptors to recognize potential threats. To accomplish the processes that are involved in cell migration, including chemoattraction, rolling adhesion, tight adhesion collective cell migration, and/or extravasation and transmigration, cells need to successfully navigate the complex 3D environment of living tissues.

To study the detailed molecular and biophysical mechanisms related to T cell migration mouse models are often used. However, their biology does not always translate to humans and on top of that mouse models cost a lot of time and money and are ethically debatable. In vitro cell culture models do not recapitulate complex human biology, due to the lack of vasculature, extracellular matrix, and neighboring cells.


In this webinar, you will learn everything about:

  • How microfluidic organ-on-a-chip models can be developed to study 3D cell dynamics
  • Development of an assay that allows unimpeded extravasation of T cells under flow in real-time and using a high-throughput, artificial membrane‐free microfluidic platform as an example
  • Observation, imaging, and analysis of 3D cell migration.

Register Here


Speakers

Lenie van den Broek, Director Biology Discovery at MIMETAS

 

 

 

 

Luuk de Haan, Scientist Model Development at MIMETAS
Luuk graduated from Utrecht University in 2018 after completing the Molecular and Cellular Life Sciences Master’s program. Shortly after, he started as a scientist in the Model Development team of MIMETAS where his work is mostly focused on the development of innovative, immunocompetent tissue models.



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