• We offer tailored partnerships to support and transform drug discovery.

    Every collaboration is a bespoke arrangement, meticulously designed to discover new compounds and targets in patient relevant disease models.

  • MIMETAS offers flexible fee-for-service solutions for therapy prioritization, optimization, and de-risking of compounds.

    As an extension of your team, MIMETAS provides the expertise and resources needed for effective research and development.

  • Our OrganoReady program is made for you when you need optimized assays for investigational toxicology.

    We guarantee OrganoReady performance according to specifications, in a fast and convenient sales transaction with a clear fee structure.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
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OrganoReady® Blood Vessel HUVEC

40 or 64 ready-to-use HUVEC tubules to assess vascular toxicity, compound transport, and immune migration.

Do you want to perform experiments in human-relevant, complex 3D tissue models but don’t have the time or experience to build your own? Look no further, with the OrganoReady Blood Vessel HUVEC you can now take your vascular research to the next level. Perform your self-created experiments to investigate permeability, absorption and transport, ​toxicity, and barrier integrity (TEER) in a physiologically relevant model.

OrganoReady® Blood Vessel HUVEC features:

  • OrganoPlate® 3-lane 40 or 3-lane 64, including:
    • 40 or 64 chips with ready-to-use HUVEC tubules
  • Direct access to the apical and basal lumen of tubules
  • HUVEC cell line: Human umbilical vein endothelial cells
  • ECM: Collagen I (Rat Tail)

Each tissue culture chip contains one in-gel culture channel and two perfusion channels, of which one perfused HUVEC tubule. Compounds and stimuli can be added directly from the apical and basolateral sides of the culture. With this direct access, the platform enables perfusion and supports various barrier function and transport assays.

Our Technology

Product details

Meet the OrganoReady Blood Vessel HUVEC

Ready-to-assay blood vessel tubules
40 or 64 ready-to-use HUVEC tubules, seeded against collagen I, allowing you to perform assays right away.

We create the model, so you can focus on your assays
Preparation and QC of OrganoReady Blood vessel HUVEC are done by our experts. Use the OrganoReady Blood vessel HUVEC directly after arrival for up to 7 days.

Get inspired by a wide range of possible applications
Study for example (drug-induced) toxicity, transport, use it for disease modeling or for fundamental research on the vasculature.

Apical and basal access
Perfused HUVEC tubules, allowing barrier integrity (TEER), transporter (e.g. P-gp), and permeability assays.

No artificial membranes for free migration, invasion, and exchanges of factors
Unique PhaseGuide™ technology allows cells to interact and migrate freely between channels.

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OrganoReady Blood Vessel HUVEC:
how it works

In this video, we show an example of the blood vessel tubules grown against an extracellular matrix (ECM). To assess the tightness of the monolayer we performed a barrier integrity assay.

For this assay, we replace the medium with a medium containing a fluorescent dye. Subsequently, we monitor the leakage of the dye from the top channel, which represents the lumen of the tubule, into the adjacent ECM gel. In the first two columns, leaky tubes were cultured, in contrast to the leak-tight tubes in the rest of the plate.

About Perfused Tubules

Want to know more?

Get up to speed with 3D tissue culture and learn how OrganoPlate® supports your research needs.

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