• We offer tailored partnerships to support and transform drug discovery.

    Every collaboration is a bespoke arrangement, meticulously designed to discover new compounds and targets in patient relevant disease models.

  • MIMETAS offers flexible fee-for-service solutions for therapy prioritization, optimization, and de-risking of compounds.

    As an extension of your team, MIMETAS provides the expertise and resources needed for effective research and development.

  • Our OrganoReady program is made for you when you need optimized assays for investigational toxicology.

    We guarantee OrganoReady performance according to specifications, in a fast and convenient sales transaction with a clear fee structure.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
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OrganoReady® Blood Vessel HUVEC

40 or 64 ready-to-use HUVEC tubules to assess vascular toxicity, compound transport, and immune migration.

Do you want to perform experiments in human-relevant, complex 3D tissue models but don’t have the time or experience to build your own? Look no further, with the OrganoReady Blood Vessel HUVEC you can now take your vascular research to the next level. Perform your self-created experiments to investigate permeability, absorption and transport, ​toxicity, and barrier integrity (TEER) in a physiologically relevant model.

OrganoReady® Blood Vessel HUVEC features:

  • OrganoPlate® 3-lane 40 or 3-lane 64, including:
    • 40 or 64 chips with ready-to-use HUVEC tubules
  • Direct access to the apical and basal lumen of tubules
  • HUVEC cell line: Human umbilical vein endothelial cells
  • ECM: Collagen I (Rat Tail)

Each tissue culture chip contains one in-gel culture channel and two perfusion channels, of which one perfused HUVEC tubule. Compounds and stimuli can be added directly from the apical and basolateral sides of the culture. With this direct access, the platform enables perfusion and supports various barrier function and transport assays.

Download the Flyer Preclinical Research

Product details

Meet the OrganoReady Blood Vessel HUVEC


Ready-to-assay blood vessel tubules
40 or 64 ready-to-use HUVEC tubules, seeded against collagen I, allowing you to perform assays right away.

We create the model, so you can focus on your assays
Preparation and QC of OrganoReady Blood vessel HUVEC are done by our experts. Use the OrganoReady Blood vessel HUVEC directly after arrival for up to 7 days.

Get inspired by a wide range of possible applications
Study for example (drug-induced) toxicity, transport, use it for disease modeling or for fundamental research on the vasculature.

Apical and basal access
Perfused HUVEC tubules, allowing barrier integrity (TEER), transporter (e.g. P-gp), and permeability assays.

No artificial membranes for free migration, invasion, and exchanges of factors
Unique PhaseGuide™ technology allows cells to interact and migrate freely between channels.



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Get inspired


Selected Publication

High throughput transepithelial electrical resistance (TEER) measurements on perfused membrane-free epithelia.

Poster

A 3D T cell migration model to study transendothelial migration in healthy and diseased conditions


 

More info? Contact us here

OrganoReady Blood Vessel HUVEC:
how it works


In this video, we show an example of the blood vessel tubules grown against an extracellular matrix (ECM). To assess the tightness of the monolayer we performed a barrier integrity assay.

For this assay, we replace the medium with a medium containing a fluorescent dye. Subsequently, we monitor the leakage of the dye from the top channel, which represents the lumen of the tubule, into the adjacent ECM gel. In the first two columns, leaky tubes were cultured, in contrast to the leak-tight tubes in the rest of the plate.

About Perfused Tubules

Want to know more?


Get up to speed with 3D tissue culture and learn how OrganoPlate® supports your research needs.

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Living innovation

What customers say
'
Our exciting collaboration enables our research and early development group to apply state-of-the-art organ-on-a-chip technology in the modeling of IBD and HBV. These models have the potential to improve our understanding of disease biology and transform

James Sabry, Global Head
Roche Pharma Partnering

The 'I' in MIMETAS
'
Tackling challenges together.

Linda Gijzen
Scientific Project Lead

What customers say
'
"The OrganoReady Colon Caco-2, combined with the OrganoTEER, have become our gold standard in vitro model for the screening of intestinal barrier disruptors at SIAF. "

Cezmi Akdis
Director SIAF
University Zurich

What customers say
'
The OrganoPlate Caco-2 model is for us, at Merck, the most suitable platform offering at the same time scalability, speed, robustness, ease of handling, with low compound needs.

Philip Hewitt
Head of Early Investigative Toxicology
Merck KGaA

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Chiwan Chiang
Marketing Specialist
'
A day without
laughter is a day wasted.
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What customers say
'
Mimetas' tumor infiltration platform demonstrated a therapeutic effect of our compound on immune cell recruitment: we’re very excited by these proof of concept data

Scientist
From a top pharma

The 'I' in MIMETAS
Jos Joore
CEO
'
We want to
empower research on complex tissue biology.
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What customers say
'
Often you have to compromise it’s either the throughput or it’s the complexity of the model. Getting both in the same platform… no other platform can do that!

Scientist
From a top pharma

The 'I' in MIMETAS
Nienke Wevers
Senior Scientist
'
Nothing ventured, nothing gained.
Read more
What customers say
'
We were able to measure cell barrier permeabilities in a lung-on-a-chip model demonstrating superior sensitivity and translatability than any other lung cell model we tried before. It was also very easy to scale up our data generation workflow.

Scientist
From a top commercial organization

The 'I' in MIMETAS
Henriëtte Lanz
Director of Model Development
'
It should be
mandatory to
socialize with colleagues.
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What customers say
'
Organoplates opened avenues that were before considered unreachable

Laura Perin, PhD
Children’s Hospital Los Angeles

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Bas Trietsch
Chief Technology Officer
'
We try to help
each other
as a team.
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Chief Financial Officer
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It always seems impossible until it’s done.
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Paul Vulto
CEO
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Leveraging who you are, is the key to making a difference!
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Linda Gijzen
Scientific Project Lead
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Tackling challenges together.
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The 'I' in MIMETAS
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Associate Director of Sales
'
It is not really
work if you are
having fun.
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Liis Rannamäe
Laboratory Technician
'
Can be summarized in three words - engaging, playful, and innovative.
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Mieke Doornbos
Vice President Sales & Marketing
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Celebrate
good times.
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Frederik Schavemaker
Product Design Engineer
'
Pioneering, bringing the best solutions
for scientific
discovery.
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The 'I' in Mimetas
Remko van Vught
Vice President Business Development
'
Making
a difference
together.
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The 'I' in MIMETAS
Lenie van den Broek
Director Biology Discovery
'
Dynamic and innovative - each day holds a surprise.
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The 'I' in Mimetas
Arnaud Nicolas
Associate Director TechCore
'
Own your flaws.
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Latest Whitepaper
'
Closing the Translational Gap in Cancer Drug Discovery with Comprehensive Tumor Models

Discover insights from six oncology applications of MIMETAS’ 3D tumor models.


Download the whitepaper

New Webinar
'
Phenotypic Disease Modeling for Immuno-Oncology: Putting Targets into Patient Context


Now available on demand.

Watch it here

Press Release
'
MIMETAS and Astellas Enter into Strategic Partnership on Immuno-oncology

The partnership comprises utilizing MIMETAS’ comprehensive tumor models to support the next generation of immuno-oncological therapies.

Read the full article here

News Article
'
First Large-scale Phenotypic Screen Using Organ-on-a-Chip

Leveraging a 3D angiogenesis assay, MIMETAS executed a 1537 kinase inhibitor library screen.


Read the article

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