Chat with us, powered by LiveChat
  • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
open menu icon close menu icon
EN

OrganoReady® Blood Vessel HUVEC

40 or 64 ready-to-use HUVEC tubules to assess vascular toxicity, compound transport, and immune migration.

Do you want to perform experiments in human-relevant, complex 3D tissue models but don’t have the time or experience to build your own? Look no further, with the OrganoReady Blood Vessel HUVEC you can now take your vascular research to the next level. Perform your self-created experiments to investigate permeability, absorption and transport, ​toxicity, and barrier integrity (TEER) in a physiologically relevant model.

OrganoReady® Blood Vessel HUVEC features:

  • OrganoPlate® 3-lane 40 or 3-lane 64, including:
    • 40 or 64 chips with ready-to-use HUVEC tubules
  • Direct access to the apical and basal lumen of tubules
  • HUVEC cell line: Human umbilical vein endothelial cells
  • ECM: Collagen I (Rat Tail)

Each tissue culture chip contains one in-gel culture channel and two perfusion channels, of which one perfused HUVEC tubule. Compounds and stimuli can be added directly from the apical and basolateral sides of the culture. With this direct access, the platform enables perfusion and supports various barrier function and transport assays.

Our Technology

Product details

Meet the OrganoReady Blood Vessel HUVEC


Ready-to-assay blood vessel tubules
40 or 64 ready-to-use HUVEC tubules, seeded against collagen I, allowing you to perform assays right away.

We create the model, so you can focus on your assays
Preparation and QC of OrganoReady Blood vessel HUVEC are done by our experts. Use the OrganoReady Blood vessel HUVEC directly after arrival for up to 7 days.

Get inspired by a wide range of possible applications
Study for example (drug-induced) toxicity, transport, use it for disease modeling or for fundamental research on the vasculature.

Apical and basal access
Perfused HUVEC tubules, allowing barrier integrity (TEER), transporter (e.g. P-gp), and permeability assays.

No artificial membranes for free migration, invasion, and exchanges of factors
Unique PhaseGuide™ technology allows cells to interact and migrate freely between channels.



Request QuoteStay up to date

OrganoReady Blood Vessel HUVEC:
how it works


In this video, we show an example of the blood vessel tubules grown against an extracellular matrix (ECM). To assess the tightness of the monolayer we performed a barrier integrity assay.

For this assay, we replace the medium with a medium containing a fluorescent dye. Subsequently, we monitor the leakage of the dye from the top channel, which represents the lumen of the tubule, into the adjacent ECM gel. In the first two columns, leaky tubes were cultured, in contrast to the leak-tight tubes in the rest of the plate.

About Perfused Tubules

Want to know more?


Get up to speed with 3D tissue culture and learn how OrganoPlate® supports your research needs.

Knowledge Center Contact us

Living innovation

Cookies

‘May we use cookies?
Hi there! Thanks for visiting our website. We use cookies to keep track of our website statistics to optimize the user experience. We also use cookies for marketing purposes. You can set your preferences by selecting the options below. Terms of Use & Privacy Policy

Accept all
Accept selected
Decline all