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  • Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
  • We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
  • Get robust compound data in human tissue models through our OrganoServices. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
  • We offer several services to support your drug discovery and development needs. Find the overview here.
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  • Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.

  • Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

  • Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.

  • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

  • The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.

  • OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

  • Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.

    Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.

  • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.

  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Frequently asked questions answered by our experts. Find here the answer you're looking for.
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Poster: A 3D T cell migration model to study transendothelial migration in healthy and diseased conditions

Novel in vitro model to better recapitulate the behavior of T cells in vivo

Poster: A 3D T cell migration model to study transendothelial migration in healthy and diseased conditions The use of a patients’ own immune system is a promising avenue to combat cancer, even though therapeutic efficacy varies significantly depending on the tumor type and between patients. Novel models that manage to better recapitulate the behavior of T cells in vivo could spur the development and improvement of these immune therapies.

In this poster, we present a novel in vitro 3D T cell migration model comprising an endothelial tubule perfused with T cells that can be used to study their migration in healthy and inflammatory conditions in a high-throughput manner.

Using the OrganoPlate® platform, directional T cell migration across endothelial vessel walls into adjacent tissue can be tracked and quantified. Also, migration can be modulated by the addition of a wide range of triggers. Furthermore, the platform enables the incorporation of other tissues or cells, such as tumor cells. The development of the model in a high-throughput 3D tissue culture platform could support future screening purposes.

 

Download the poster here

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