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Blood Vessel HUVEC Barrier Integrity

OrganoServicesTM are available for multiple assays to allow compound profiling and/or screening in human-relevant, complex 3D tissue models.

Barrier function is an important readout in (bio)medical research, as the pathogenesis of many human diseases involves tissue barrier disruption. Measuring transendothelial electrical resistance (TEER) is a sensitive method to assess a tissue’s barrier function. We recently introduced the OrganoTEER®, a device engineered to measure barrier function of in vitro models. The OrganoTEER® is not only extremely efficient but can also measure a high range of TEER values, which makes it a valuable tool to answer your research questions regarding endothelial barrier integrity.

OrganoService Blood Vessel HUVEC Barrier Integrity offers:

  • Screening of your compounds in our developed Blood Vessel HUVEC model
  • Screening of up to 16 compounds in one concentration per OrganoPlate
  • 2 Technical replicates and 2 control samples
  • Option to extend the compound screen with more plates, in case a larger screen is desired
  • Raw and normalized TEER values in a clear data report

An example of an application that can be performed using this OrganoServiceTM is the assessment of vascular toxicity of chemicals or therapeutic candidates.


About Perfused Tubules OrganoTEER

 

Service details

About OrganoService
Blood Vessel HUVEC Barrier Integrity

 

Kickstart the screening of your compounds in 3D tissue cultures
Easy access to our OrganoPlate® platform and high-quality 3D tissue cultures

Time-lapse measurements
Highly sensitive measurements of high as well as low TEER values at several timepoints

Interrogate endothelial barrier from both apical and basal side
Capability to interrogate endothelia under flow with apical and basal access

Data reporting in one go
Receive a clear data report and raw data sheets

Consistent data quality
Fully automated data acquisition and extraction ensures consistent data quality

Compiled by our scientists
Service is developed from the internal R&D knowledge base




Service flyer Contact us for more info

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