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      • Our OrganoReady program is made for you when you need defined assays in ADME.

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  • We offer tailored partnerships to support and transform drug discovery.

    Every collaboration is a bespoke arrangement, meticulously designed to discover new compounds and targets in patient relevant disease models.

  • MIMETAS offers flexible fee-for-service solutions for therapy prioritization, optimization, and de-risking of compounds.

    As an extension of your team, MIMETAS provides the expertise and resources needed for effective research and development.

  • Our OrganoReady program is made for you when you need defined assays in ADME.

    We guarantee OrganoReady performance according to specifications, in a fast and convenient sales transaction with a clear fee structure.

  • Get inspired by peer-reviewed publications, webinars, whitepapers, app notes and more in our knowledge center.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
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OrganoReady® Colon Organoid

Designed for seamless integration in your lab, OrganoReady is a ready-to-use platform delivering 64 perfusable colon tubes into your lab. With just 1-2 days of recovery, the tubules are viable with an assay window of at least 10 days, ensuring consistent and reliable results. This adult stem cell-derived model harnesses the physiological relevance of organoids while providing membrane-free apical and basal access to the model. This allows you to make more accurate predictions of drug responses, such as gastrointestinal toxicity events. Additionally, this model enables the study of human intestinal disease processes, such as for example inflammatory bowel disease.

This is the first ready-to-use adult stem cells derived solution offered license free, presenting a cost-effective solution with no hidden fees!

OrganoReady® Colon Organoid features:

  • Perfusable colon organoid tubules
  • Adult stem cell-derived tissue
  • Polarized epithelium
  • Proliferative phenotype

Download the FlyerPreclinical Research

Fully Characterized Intestinal Model

The perfusable colon organoid tubules are developed in the OrganoPlate® 3-lane 64, a platform which enables membrane free culturing of differentiated adults stem cells derived colon organoids. The tissue shows expression of relevant markers like MUC2, Occludin and Villin, demonstrating the mature nature of the intestinal tissue, with the presence of enterocytes, goblet cells and stem cells. The 3D-lumenized structure provide apical (Ezrin) and basolateral (Integrin β4) access to the polarized epithelium. Additionally, the organoid tubules show polarized and modulatable activity of Pgp, inducible CYP3A4 and functional efflux via BCRP.


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A perfusable OrganoReady Colon Organoid tubule with accessible apical and basolateral side, stained for tight junction (Occludin, green) and cell nuclei (blue).

How to access our OrganoReady Colon Organoid

Services

MIMETAS offers tailored fee-for-service solutions for therapy prioritization, optimization, and de-risking of compounds using. Our flexible fee-for-service model allows you to scale your projects according to demand and timelines. Advance your therapeutics portfolio using the OrganoReady Colon Organoid model, providing a variety of optimized assays at scale. Contact our experts to discuss how we can help you with disease modeling, compound safety and DMPK studies.

OrganoReady

MIMETAS offers ready-to-use models shipped to your laboratory with guaranteed performance according to specifications, in a fast and convenient sales transaction with a clear fee structure. The OrganoReady Colon Organoid model allows screening of compounds to de-risk safety liabilities and repurpose backup compounds with mechanistic insight. Receive the model delivered to your lab, complete with all necessary medium to support your safety studies with optimized protocols. Upon arrival, the model is ready to use after 1-2 days of recovery with an assay window of at least 10 days (TEER> 100 Ω*cm2 ).

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