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OrganoReady® Colon Organoid

OrganoReady colon organoid in the OrganoPlate 3-lane 64

The Colon Organoid model is designed for seamless integration into your lab, delivering 64 ready-to-use perfusable colon tubes. Following a few days of recovery, the tubules are leak-tight and ready for toxicological applications.

Derived from adult stem cells, this model harnesses the physiological relevance of organoids with membrane-free apical and basal access, enabling more accurate predictions of gastrointestinal toxicity (GIT) – a common and severe adverse event that poses significant challenges in drug discovery and development1, 2.

This is the first ready-to-use solution derived from adult stem cells, complete with an included license. This OrganoReady product will take your GIT screening to the next level!

OrganoReady® Colon Organoid features:

  • Perfusable colon organoid tubules
  • Adult stem cell-derived tissue
  • Polarized epithelial cytoarchitecture
  • Proliferative phenotype

Download the FlyerPreclinical Research

Fully Characterized Intestinal Model

The perfusable colon organoid tubules are developed in the OrganoPlate® 3-lane 64, a platform which enables membrane free culturing of differentiated adults stem cell-derived colon organoids. The tissue expresses relevant markers like MUC2, Occludin and Villin, demonstrating the mature nature of the intestinal tissue, with the presence of enterocytes, goblet cells and stem cells. The 3D-lumenized structure provides apical (Ezrin) and basolateral (Integrin β4) access to the polarized epithelium. Additionally, the organoid tubules show polarized and modulatable activity of Pgp, inducible CYP3A4 and functional efflux via BCRP.

Fully characterized In vitro 3D Colon Organoid model for gut toxicity assessment

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A perfusable OrganoReady Colon Organoid tubule with accessible apical and basolateral side, stained for tight junction (Occludin, green) and cell nuclei (blue).

Translatable for Toxicology Application

Drug development, especially in oncology, frequently involves gastrointestinal disorders as adverse effects, highlighting the need for advanced models to accurately predict and replicate these toxic events in a screenable platform. The OrganoReady Colon Organoid offers a more translatable solution compared to other cell-based models, providing accurate predictions of drug responses. The OrganoReady Colon Organoid model features tubular structures of the colon with accessible apical and basolateral sides, and fluid perfusion through the lumen, which enables direct compound exposure, closely mimicking oral and intravenous drug administration.

OrganoReady Colon Organoid for Gut toxicity screening

Exposure to compounds known to induce gut toxicity, particularly those causing diarrhea3, reveals a dose-dependent effect on barrier integrity (TEER) and cell viability in the colon organoid tubules. This validates OrganoReady Colon Organoid model’s capability to quantitatively capture the adverse effects of therapeutics on the gut.


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How to access our OrganoReady Colon Organoid

Services

MIMETAS offers tailored fee-for-service solutions for therapy prioritization, optimization, and de-risking of compounds. Our flexible service model allows you to scale your projects according to demand and timelines. Advance your therapeutics portfolio using the OrganoReady Colon Organoid model, which provides a range of optimized assays at scale. Contact our experts to explore how we can help you with disease modeling, compound safety, and DMPK ranking studies.

OrganoReady

MIMETAS offers ready-to-use models shipped directly to your laboratory with guaranteed performance, ensuring in a fast and convenient transaction with a transparent fee structure. The OrganoReady Colon Organoid model is an ideal platform for screening small and large molecules, helping to de-risk safety liabilities and repurpose backup compounds with mechanistic insight. After a few days of recovery upon arrival, the model is ready to use and comes complete with all necessary cell culture media and optimized protocols to support your experiments.

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