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A 3D human Renal Proximal tubule model: The NephroScreen platform uses polarized ciPTEC-OAT1 tubules with functional transporters to predict drug-induced kidney injury and drug-transporter interactions, offering reproducibility, biomarker analysis, and compatibility with automation.

The OrganoPlate® 2-lane 96 is a microfluidic cell culture platform that enables culturing and screening of a range of miniaturized 3D organs and tissue models. Here we describe the development of a functional 3D liver-on-a-chip model on the OrganoPlate®. The 3-liver cell type model was constructed by seeding differentiated induced pluripotent stem-cell derived hepatocytes (iHeps) in collagen extracellular matrix in the top channel of the chip, and endothelial and Kupffer cells in the bottom channel. Characterization of the model showed that the culture achieved a mature hepatocyte phenotype over time. The model was capable of detecting known hepatotoxins and four robust assays were identified and used in a compound library screen of 159 compounds. Identified toxic hits were ranked in hepatotoxicity by a composite score and a follow-up dose-response assessment was conducted. The platform’s compatibility with standard laboratory equipment and automation makes this liver-on-a-chip model amenable to highthroughput screening. This physiologically relevant model enables hepatotoxicity testing and provides valuable insight into drug efficacy studies for liver diseases.

A comparison of the OrganoPlate and the Transwell platform for in vitro intestinal permeability assays

A high-throughput 3D angiogenesis model: The angiogenesis model enables automated, perfused culture of endothelial cells forming sprouts in response to angiogenic cues, supported by integrated robotics and imaging systems for efficient and scalable vascular biology research.

A high-throughput 3D model: This BBB-on-a-chip system uses perfused primary human brain microvascular endothelial cells to replicate barrier integrity, transporter function, and cytokine-induced disruption, enabling compound screening and mechanistic studies of the blood-brain barrier.

A perfused 3D immune model: The OrganoPlate® platform enables real-time analysis of T cell transendothelial migration under inflammatory conditions by integrating a vessel structure with extracellular matrix and high-content imaging for quantification.