3D Human Blood-Brain-Barrier (BBB) Model
MIMETAS’ 3D human BBB model captures essential barrier physiology, enabling advanced drug transport, toxicity, and disease modeling in a scalable platform.
Neurovascular Complexity Tailored to Your Research
MIMETAS’ BBB models are comprised of primary brain endothelium with tight junction expression, and vascular flow. Additional aspects of the human neurovascular unit are added through co-culture with astrocytes, pericytes, and neurons. These features allow analysis of drug permeability, barrier disruption, and neuroinflammation.
Available Model Configurations:
Perfused monocultures of primary HBMECs
Tri-cultures with iPSC-derived astrocytes and neurons
Co-cultures with pericytes, microglia, and/or immune cells
Customized NVU complexity upon request
A Range of Formats to Fit Your Needs
Whether you need an off-the-shelf model or a customized solution, MIMETAS supports you with our services and products.
A Range of Applications to Support Your Neurotherapeutic Pipeline
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Drug transport & permeability screening
Barrier disruption and recovery assays
Antibody transcytosis
Disease modeling: CNS inflammation, glioblastoma, glioblastoma multiforme, and stroke
Selected Resources
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