Our Technology

Recapitulating the Organ Niche Through Precision Microfluidics

MIMETAS' flagship technology, the OrganoPlate® platform, is a precision microfluidic system that allows the recreation of the dynamic environment of living tissues in vitro.

It enables advanced 3D cell culture, continuous perfusion, and complex co-cultures – without the need for pumps, tubing, or artificial membranes.

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How Our Technology Works

The OrganoPlate® platform integrates 40 to 96 microfluidic chips into a familiar microtiter plate format. Each chip is powered by our patented PhaseGuide™ technology. Designed with low-absorbing materials and a thin glass bottom, the platform is optimized for high-quality imaging - delivering reliable, biologically relevant data with ease, chip after chip, plate after plate.

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No artificial membranes
Our PhaseGuide™ technology allows patterning of gels and cells by means of surface tension. Simple pipetting procedures are sufficient to create any biological complexity.
Seamlessly compatible
Built on a standard microplate format, the platform integrates effortlessly with automated workflows, microscopes, and plate readers.
Scalable throughput
From 40 to 96 chips per plate, and screening across hundreds of plates, researchers can study tens of thousands of physiologically relevant tissues.
Physiologically relevant flow
Passive leveling induces continuous flow that applies shear stress to epithelia and blood vessels, closely mimicking in vivo conditions.

Shaping Biology With Flow

Flow in the OrganoPlate platform is driven by gravity-induced leveling between reservoirs on the OrganoFlow® rocker. This means no complex pumps or tubing are required – and each chip is exposed to identical flow conditions.

Perfusion supports metabolic homeostasis, compound delivery and sampling, interstitial flow, nutrient and oxygen exchange, waste removal, and the application of physiologically relevant shear stress to epithelia and vasculature.


NEW UniFlow technology

MIMETAS has recently launched services based on its newly developed UniFlow technology. This technology assures that perfusion flow is always in the same direction, further improving conditions for (micro)vasculature.

One Platform For Every Tissue Culture

Chips in the OrganoPlate platform are devoid of artificial membranes. This allows cells to migrate, remodel, and self-organize – just as they would in native tissue. This balance of engineering precision with natural cell behavior enables a broad range of tissue models and assays – all within a single platform.

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Perfused Tubules
Cells form perfused tubules and vessels against the extracellular matrix, enabling barrier function and transport studies.
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Stratified Co-Cultures
Epithelia, stroma, immune cells, and blood vessels can be co-cultured and layered in structured tissues – ideal for studying cell-cell interactions.
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Angiogenesis
Membrane-free microvascular formation and growth
through an extracellular matrix (ECM) allowing precise quantification of such processes under compound exposure.
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Vascularization
Cultures of epithelia and connective tissue are complemented with a perfused vasculature resulting in an intricate microvascular network and polarized parenchyma.
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Cell Migration & Outgrowth
Immune cell trafficking, tumor cell metastasis, angiogenesis, and axonal outgrowth can be modeled and quantified.
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Assay Versatility

The OrganoPlate® platform supports a wide range of readouts and endpoints:

Live & Fixed Cell Imaging – Track migration, remodeling, and marker expression.
Barrier Function (TEER) – Integrated impedance measurements with the OrganoTEER® device.
Off-Plate Assays – Compatible with ELISA, qPCR, sequencing, and more.
Temporal Sampling – Monitor both acute and chronic responses.
Contact us to find out more about our assays

Ready to Bring Human 3D Biology Into Your Workflow?

Our team is ready to deploy our platform for your research or development pipeline.

Whether you want to bring our technology into your lab, or have our experts run studies for you, we’ll deliver the results you need.

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