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This guide reviews ECM options for 3D cell culture—covering natural proteins (collagen, fibrin, Matrigel®, hyaluronic acid) and synthetic hydrogels (PEG, alginate, designer peptides)—and offers practical tips for selecting and handling matrices to best mimic in vivo microenvironments.

This article describes advances in OrganoPlate® intestine-on-a-chip models—highlighting microfluidic platforms for high-throughput IBD research and new 14-day iPSC-derived gut tubules for personalized inflammation studies.

This article reviews advancements in personalized cancer treatment—from genomic and computational tumor models to 3D organ-on-a-chip platforms like OrganoPlate®—showing how individualized approaches enhance therapy development and screening.

This article compares traditional Transwell systems with MIMETAS' OrganoPlate for intestinal permeability research. The OrganoPlate accelerates model development, improves physiological relevance, and reduces costs by supporting 3D cell cultures, shear stress, and co-cultures, while allowing rapid permeability assays in less than five days.

The extracellular matrix (ECM) is a 3D network of proteins (collagen, elastin, fibronectin) and sugars that scaffolds tissues, directs cell behavior, and is mimicked in vitro with natural (e.g., collagen, Matrigel®) or synthetic hydrogels for 3D culture.

The article discusses the limitations of current in vitro angiogenesis models and highlights the OrganoPlate® as a more physiologically relevant, high-throughput platform for studying angiogenesis.