High-Throughput Liver Model for Predictive Toxicity Screening and AAV Safety Evaluation
Studying drug-induced liver injury is challenging due to the lack of predictive and scalable preclinical models. Our high-throughput liver microphysiological system replicates the human liver microenvironment, integrating hepatocytes, vascular networks, and immune components for accurate detection of small molecule and AAV-mediated hepatotoxicity.This innovative model captures toxicity, inflammation, and gene therapy responses, making it a powerful tool for liver safety assessment and drug development. In this poster, explore how this model is advancing liver toxicity screening and gene therapy evaluation.Key Features of the Model3D liver tissue with hepatocytes, liver endothelial, stellate, and Kupffer-like cellsPerfusable vascular networks for compound and AAV delivery via vasculatureHigh-throughput compatibility with automation for efficient screeningPredictive toxicology readouts, including albumin secretion, cytokine release, and margin of safety (MOS)
High-Throughput Liver Model for Predictive Toxicity Screening and AAV Safety Evaluation
High-Throughput Liver Model for Predictive Toxicity Screening and AAV Safety Evaluation
A high-throughput liver-on-a-chip model that mimics the human liver microenvironment to predict drug-induced and AAV-mediated toxicity, integrating vascularized 3D liver tissue with immune components for scalable and automated safety screening.
High-Throughput Liver Model for Predictive Toxicity Screening and AAV Safety Evaluation
A high-throughput liver-on-a-chip model that mimics the human liver microenvironment to predict drug-induced and AAV-mediated toxicity, integrating vascularized 3D liver tissue with immune components for scalable and automated safety screening.
High-Throughput Liver Model for Predictive Toxicity Screening and AAV Safety Evaluation
A high-throughput liver-on-a-chip model that mimics the human liver microenvironment to predict drug-induced and AAV-mediated toxicity, integrating vascularized 3D liver tissue with immune components for scalable and automated safety screening.
High-Throughput Liver Model for Predictive Toxicity Screening and AAV Safety Evaluation
A high-throughput liver-on-a-chip model that mimics the human liver microenvironment to predict drug-induced and AAV-mediated toxicity, integrating vascularized 3D liver tissue with immune components for scalable and automated safety screening.
High-Throughput Liver Model for Predictive Toxicity Screening and AAV Safety Evaluation
A high-throughput liver-on-a-chip model that mimics the human liver microenvironment to predict drug-induced and AAV-mediated toxicity, integrating vascularized 3D liver tissue with immune components for scalable and automated safety screening.
High-Throughput Liver Model for Predictive Toxicity Screening and AAV Safety Evaluation
A high-throughput liver-on-a-chip model that mimics the human liver microenvironment to predict drug-induced and AAV-mediated toxicity, integrating vascularized 3D liver tissue with immune components for scalable and automated safety screening.
High-Throughput Liver Model for Predictive Toxicity Screening and AAV Safety Evaluation
A high-throughput liver-on-a-chip model that mimics the human liver microenvironment to predict drug-induced and AAV-mediated toxicity, integrating vascularized 3D liver tissue with immune components for scalable and automated safety screening.
High-Throughput Liver Model for Predictive Toxicity Screening and AAV Safety Evaluation
A high-throughput liver-on-a-chip model that mimics the human liver microenvironment to predict drug-induced and AAV-mediated toxicity, integrating vascularized 3D liver tissue with immune components for scalable and automated safety screening.