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  • Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
  • We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
  • Get robust compound data in human tissue models through our services. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
  • We offer several services to support your drug discovery and development needs. Find the overview here.
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  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.

  • Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

  • Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.

  • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

  • The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.

  • OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

  • Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.

    Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.

  • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.
  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Frequently asked questions answered by our experts. Find here the answer you're looking for.
  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
EN

High throughput phenotypic screening in Organ-on-a-Chip: future or reality?

On-demand Webinar

Organ-on-a-Chip is a powerful technology driving physiological relevance by utilizing microfluidic techniques. The technology is expected to impact drug development and ultimately replace or reduce animal testing. Since the majority of platform technologies are either based on single or small numbers of chips in dedicated surroundings, applications for Organ-on-a-Chip are largely envisioned in pre-clinical testing, such as preclinical safety, pharmacology, or pharmacokinetics. Thus far it was thought that the advanced complexity of models limits scalability and thus their utility for drug discovery studies. Until now.

The OrganoPlate® is an Organ-on-a-Chip technology that enables scientists to develop physiologically relevant human (disease) models in a platform being fully compatible with automated imaging and robotic handling. In this webinar, scientific experts from MIMETAS and Molecular Devices will present the largest Organ-on-a-Chip screening effort, demonstrated by a high-throughput screen of 1546 compounds on a 3D angiogenic sprouting assay, and show how complex 3D tissue models can be interrogated using the latest advancements in cellular imaging and analysis systems

In this webinar, you will learn:

  • How the OrganoPlate® technology can be used with automated platforms enabling high throughput screening efforts.
  • How a complex angiogenic sprouting assay was developed in the new OrganoPlate® 3-lane 64 and used for screening of a protein kinase inhibitor library.
  • How Molecular Devices ImageXpress high-content imaging systems play a vital role in OrganoPlate® phenotypic screening assays, by enabling translatable assays and readouts as well as quantitative characterization of complex phenotypic effects.

Register here


Speakers

Dr. Sebastiaan Trietsch, CTO and co-founder of MIMETAS.
Bas is co-inventor of the OrganoPlate®, optimized it towards a mass manufacturable product, and enabled the establishment of MIMETAS’ production facility. He developed the initial tissue models on the OrganoPlate and continues to support assay development in the OrganoPlate. As CTO he currently drives the continued product development of the OrganoPlate and its peripheral equipment. Bas holds a master’s degree and Ph.D. in biopharmaceutical sciences from Leiden University and co-authored over 30 peer-reviewed publications and patents.

Dr. Henriette Lanz, Director of Model Development at MIMETAS.
Henriette has received her Ph.D. in Molecular Biology from Leiden University in 2012, and a cum laude Masters in Life Science Technologies. She worked on cancer-selective target discovery at Leiden University and secondary metabolite production at Explant Technologies. In her current role at Mimetas, she supervises a team of senior and junior scientists and technicians, alongside Ph.D. and MSc students. The specific focus of her research activities at Mimetas are the development of organotypic models for drug screening and toxicity evaluation within the fields of kidney, vasculature, and cancer.

Christian Holz, MSc, Imaging Applications Scientist at Molecular Devices.
Christian holds a BSc in Zoology and an MSc in Structural Molecular Biology. He has been an Imaging Applications Scientist with Molecular Devices for more than ten years supporting a vast number of academic and industry customers in a broad range of assay setups. Formerly he was involved in running large image-based RNAi screening campaigns and developing specialized image analysis routines.


Related publications


Register below to watch the webinar on-demand

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