This flyer presents a comparative analysis of manual versus automated placement of spheroids within the OrganoPlate Graft. Utilizing the YAMAHA Cell Handler™ (YCH) for automated placement demonstrates significant improvements in precision and efficiency over manual methods.​Key Highlights:Enhanced Precision: Automated placement with YCH achieves more accurate central positioning of spheroids compared to manual methods.​Increased Efficiency: Spheroid transfer time is significantly reduced from 30 minutes (manual) to under 7 minutes (automated).​Selective Placement: YCH enables selection of spheroids based on size and morphology, ensuring consistency across experiments.​High-Throughput Capability: The OrganoPlate Graft 64-chip format is compatible with automated workflows, facilitating large-scale studies.​This comparative study underscores the advantages of integrating automated systems like the YCH with the OrganoPlate Graft for improved reproducibility and throughput in 3D tissue culture applications.​