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  • Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
  • We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
  • Get robust compound data in human tissue models through our services. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
  • We offer several services to support your drug discovery and development needs. Find the overview here.
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  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.

  • Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

  • Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.

  • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

  • The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.

  • OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

  • Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.

    Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.

  • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.
  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Frequently asked questions answered by our experts. Find here the answer you're looking for.
  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
EN

MIMETAS and Hubrecht Organoid Technology to develop and market Organoids-on-a-Chip


Leiden, Utrecht, October 1, 2019 MIMETAS and Hubrecht Organoid Technology (HUB) announce that they entered into a strategic collaboration to market organoid models on a Chip. The agreement includes a license to MIMETAS to market HUB Organoids in an assay ready format, as well as a collaborative effort to develop disease-specific models.

"We're delighted and proud that we could transition our long-standing collaboration with the group of Professor Hans Clevers into a commercial proposition," says MIMETAS CEO Paul Vulto. "The adult stem cell biology and Organoid technology of HUB is the very best in the world. By combining it with our OrganoPlate technology in an assay-ready format, the technology becomes available to researchers from any laboratory in the world.”

“We are excited to work with MIMETAS and add a range of new assay systems to the HUB Organoid platform,” says Dr. Rob Vries, CEO at HUB. “The OrganoPlate platform is unrivaled in its field. It is a perfect fit with our biology and enhances the ease of use, imageability, and screenability of complex Organoid models. Together we will develop diseased and healthy patient-relevant models that serve the needs of the drug development industry.”

Figure: Human colon organoid in MIMETAS OrganoPlates. Organoids are grown from adult stem cells derived from donor tissue. The organoids are grown as a tube in the MIMETAS OrganoPlate, allowing access to both the basal and apical sides of the mini-gut. The MIMETAS platform does not comprise any artificial membranes and allows for excellent imaging.

 

About MIMETAS
MIMETAS (Leiden, the Netherlands, Gaithersburg, USA, Tokyo, Japan) provides organ-on-a-chip products for compound testing, screening, and fundamental research. Its flagship product, the OrganoPlate®, supports 3D cell culture under continuous perfusion, with membrane-free co-culture and epithelial and endothelial tubules. The company develops and validates customized disease, toxicology, and transport models and ultimately will make its technology available for personalized therapy selection. MIMETAS has developed models for the kidney, liver, gut, brain, and a range of oncological applications, that offer better predictivity towards human physiology as compared to laboratory animals and conventional cell culture models. MIMETAS works with the majority of the global top-50 pharmaceutical companies, in addition to chemical, food, and consumer goods companies. The fast market acceptance of the OrganoPlate® is driven by its unsurpassed ease-of-use and throughput, in combination with complex human biology and disease relevance.

About HUB
HUB is founded on the pioneering work of Prof. Hans Clevers, who discovered methods to grow stem cell-derived human ‘mini-organs’ (HUB Organoids). The proprietary HUB Organoid Technology enables the generation of in-vitro models of any epithelial disease from any patient. HUB Organoids mimic organ functionality and are considered to be a clinically relevant model for human diseases such as Cystic Fibrosis, oncology and toxicology.

HUB Organoids or a “Patient in the Lab”, allow for better understanding of tumor heterogeneity and drug response. HUB has established a “Living Biobank” that links patient-specific genetic and phenotypic information to pre-clinical drug discovery, compounds validation, and clinical drug-response. In drug development, HUB organoids can efficiently identify novel therapeutic targets, provide drug efficacy, safety, and mechanistical data.

In addition to drug screening services, HUB offers licenses to its patented HUB Organoid Technology for drug-screening and access to Organoids in the HUB biobanks for pre-clinical drug discovery and validation. In addition, HUB is performing clinical studies to validate the technologies used as a companion diagnostic. More info at www.hub4organoids.eu.

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