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App Note: Perfused primary human blood-brain barrier in MIMETAS OrganoPlates

Mimetas’ OrganoPlates® are microfluidic cell culture plates that enable culturing of a range of miniaturized 3D organ and tissue models. Here we describe the development of a primary human model of the blood-brain barrier (BBB) comprising a microvessel of brain endothelial cells, supported by astrocytes and pericytes. The model shows expression of adherens- and tight junction proteins, barrier formation, and functional P-gp transport. The platform’s compatibility with standard laboratory equipment and automation makes this perfused BBB-on-a-chip amenable to high-throughput screening purposes.

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