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      • Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
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      • We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
    • Compound profiling & Screening
      • Get robust compound data in human tissue models through our OrganoServices. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
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      • We offer several services to support your drug discovery and development needs. Find the overview here.
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      • Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.

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      • Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

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      • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

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      • The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.

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      • OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

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      • Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.

        Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.

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  • Knowledge Center
  • About Mimetas
  • Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
  • We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
  • Get robust compound data in human tissue models through our OrganoServices. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
  • We offer several services to support your drug discovery and development needs. Find the overview here.
  • Start today with 3D tissue modeling>
    Kickstart successfully your first experiments with the OrganoPlate® through our OrganoStart packages.
  • OrganoFlow® >
    Driving precisely-controlled perfusion flow in the OrganoPlate® platform

  • OrganoTEER® >
    Enabling fast, automated, and impedance-based TEER measurements in OrganoPlate®. Assay 40 tissue culture chips with a few clicks, in less than one minute.

  • Start today with 3D tissue modeling>
    Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • OrganoPlate® is the solution for all in vitro tissue culture applications. Explore the entire OrganoPlate® family and its dedicated instruments here.

  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.

  • Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

  • Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.

  • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

  • The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.

  • OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

  • Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.

    Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.

  • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.
  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Frequently asked questions answered by our experts. Find here the answer you're looking for.
  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
EN

Enhancing 3D Disease Models: Automated, High-throughput Phenotypic Screening with Organ-on-a-Chip

May 17th 2022, 8am (PDT) / 11am (ET) / 5pm (CET) - Live Webinar

To enhance drug development & discovery, there is a critical need for biological model systems that better resemble human biology. Organ-on-a-Chip technology has shown its enormous potential to impact the drug discovery and development process. Most platform technologies are either based on single or small numbers of culture chips in dedicated surroundings - limiting their scalability and thus their utility for drug discovery studies… Until now.

The OrganoPlate® platform is an Organ-on-a-Chip technology that enables scientists to develop physiologically relevant human (disease) models in a platform being fully compatible with automated and sophisticated imaging, as well as robotic handling and compound screening.

Join us on May 17th we explore how Organ-on-a-Chip technology provides scientists with scaled-up and powerful new insights from relevant biological models and more accurate predictions on the safety and efficacy of investigational drugs in humans.

During this webinar, you will learn:
1. How Organ-on-a-Chip technology is improving the drug discovery and development process and its potential to replace animal testing
2. How to integrate a high-throughput screen of 1546 compounds on a 3D angiogenic sprouting assay
3. How a robust phenotypic endothelium-on-a-chip model was developed and used to establish a complex T-cell migration assay
4. How to scale-up your research with an automated OoC workflow that leverages high-throughput imaging and analysis

Please register with your professional email address.

Register here

Speakers

  • Dr. Kristin Bircsak, Principal Scientist at MIMETAS
    Kristin received her Ph.D. in Toxicology in 2016 from Rutgers University following which she completed a postdoctoral fellowship at the University of Pennsylvania in the laboratory of Dr. George Gerton. In her training, Kristin utilized various model systems to characterize the negative impact of drugs and environmental chemicals on reproduction and development. In her role at MIMETAS, Kristin drives the development of innovative 3D in vitro organotypic models and assays to aid in the accurate prediction of safe and effective therapies.
  • Dr. Angeline Lim, Senior Applications Scientist at Molecular Devices
    Angeline has over 10 years of research experience in genetics and cell biology and holds a PhD from the University of California at Santa Cruz. In her current role at Molecular Devices, her specific focus and specialisation is in bioimaging. Here, she provides scientific support for the company’s portfolio of ImageXpress® High-Content Imaging Systems and their applications in lab automation, high-throughput phenotypic profiling and 3D models in biology.
  • Dr. Alessandro Prestipino, Postdoctoral Researcher at Merck Healthcare
    Alessandro holds a PhD in Biology from the University of Freiburg, Germany, where he has been working on both immunology and immune-oncology, studying the connection between oncogenic signaling and immune escape, and its clinical implications. At Merck, he works on multiple drug discovery projects, supporting target identification and validation, and developing cellular-based assays at different levels of throughput and complexity. Currently, Alessandro is laboratory head ad interim, and interested in applying “organ-on-chip”-based assays to characterize the behavior of certain compounds in advanced phenotypic models.

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