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  • Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
  • We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
  • Get robust compound data in human tissue models through our services. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
  • We offer several services to support your drug discovery and development needs. Find the overview here.
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  • Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.

  • Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

  • Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.

  • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

  • The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.

  • OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

  • Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.

    Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.

  • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.
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EN

High throughput microfluidic gut-on-a-chip models for drug discovery and target validation in inflammatory bowel disease

On-demand Webinar

New treatments against inflammatory bowel disease (IBD) rarely make it to market due to a lack of reliable and predictive models for early drug screening. The models currently used, such as 2D in vitro models, organoids, and in vivo models suffer from significant drawbacks. These drawbacks include the failure to reproduce human physiology, interspecies differences, undesired complexity, and low throughput. Organ-on-a-chip technology provides a valuable solution to these issues with modular complexity, recapitalizing tissues in 3D to more closely resemble in vivo conditions, and the ability to perform high throughput screens.

This webinar is part of a series where we discuss organ on-a-chip-technology in intestinal drug discovery. In the first webinar, you learned how to develop and assess the physiological relevance of an intestine-on-a-chip model. In this webinar, Claudia Beaurivage, Scientist at Galapagos, will discuss the advantages of organ-on-a-chip technology and how these can be utilized in drug development against IBD.

For this research, two models of increasing physiological relevance were developed from standardized cell lines or patient material. With the use of these models, cytokine release was assessed in response to several compounds to stimulate or inhibit tissue inflammation. These models showed to be successful in determining the efficacy of drug compounds in a cell-type-specific manner.


In this webinar, you will learn everything about:

  • The advantages of organ-on-a-chip technology over other techniques to study inflammatory bowel disease
  • How organ-on-a-chip model can be applied in drug development
  • How to improve the physiological relevance of your organ-on-a-chip model with patient-derived cells

Register Here


Speaker

Claudia Beaurivage, Scientist at Galapagos





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