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  • About Mimetas
  • Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
  • We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
  • Get robust compound data in human tissue models through our services. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
  • We offer several services to support your drug discovery and development needs. Find the overview here.
  • Start today with 3D tissue modeling
    Kickstart your first experiments with the OrganoPlate® through our OrganoStart packages.

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    Driving precisely-controlled perfusion flow in the OrganoPlate® platform

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    Enabling fast, automated, and impedance-based TEER measurements in OrganoPlate®. Assay 40 or 64 tissue culture chips with a few clicks, in less than two minutes.

  • Start today with 3D tissue modeling
    Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.

  • OrganoPlate® is the solution for all in vitro tissue culture applications. Explore the entire OrganoPlate® family and its dedicated instruments here.

  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.

  • Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

  • Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.

  • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

  • The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.

  • OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

  • Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.

    Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.

  • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.

  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Frequently asked questions answered by our experts. Find here the answer you're looking for.
  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
EN

An intestine-on-a-chip model of plug-and-play modularity to study inflammatory processes

On-demand Webinar

The development of drugs for the treatment of intestinal inflammatory conditions remains difficult due to the lack of reliable, robust, and high throughput in vitro models. Current models lack physiological relevance because they do not recapitulate key aspects of the intestine. Organ-on-a-chip technology can be utilized as a solution to this issue by modeling tissues in 3D to more closely resemble in vivo conditions. In this webinar, Linda Gijzen will discuss the development of a complex co-cultured organ-on-a-chip model to study the inflamed intestine.

The model contains multiple intestinal and immune cell types to increase physiological relevance. With the use of this model, biological modularity was achieved, representing key aspects of the inflamed intestine. This platform is compatible with high throughput, robust assays in which complexity that can be tailored to serve all preclinical stages in the drug discovery process.


In this webinar, you will learn:

  • How to develop an intestine-on-a-chip model in the OrganoPlate®
  • How to measure intestinal inflammation using high throughput TEER measurements
  • How to verify the physiological relevance of your 3D tissue model

Register Here


Speaker

Linda Gijzen, Scientific Project Lead at MIMETAS
Linda completed her Master’s degree in biomedical sciences, specializing in toxicology and human pathobiology in 2016 and is currently working as a Scientific Project Lead at MIMETAS. In this role, she is involved in the development and characterization of 3D human based microfluidic models of the kidney, intestine, heart, and immune oncology. Besides her position as Scientific Project Lead, she is doing a Ph.D. at Mimetas and the University of Utrecht focusing on microfluidic disease models of the kidney and intestine.


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