On-Demand Webinar
High-throughput, physiologically relevant in vitro models are required to improve the predictive value of toxicity testing. One such platform that may address the drawbacks of current toxicology models, is the OrganoPlate®, a high-throughput, perfusion-based microfluidic cell culture tool. This webinar will discuss in detail the development and application of well-established MIMETAS kidney-, liver-, and gut-on-a-chip model systems in toxicity testing. Additionally, we will review new toxicity models including brain- and placenta-on-a-chip.
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Speaker
Dr. Kristin Bircsak, Principal Scientist at MIMETAS
Kristin received her Ph.D. in 2016 in Toxicology from Rutgers University following which she completed a postdoctoral fellowship at the University of Pennsylvania. In her training, Kristin utilized various model system to characterize the negative impact of drugs and environmental chemicals on reproduction and development. In her role at MIMETAS, Kristin drives the development of innovative 3D in vitro organotypic models and assays. Her research is centered on recapitulating the liver and prostate tumor microenvironment to aid in the accurate prediction of safe and effective candidate compounds.
Related publications
- Vormann, M. K., Vriend, J., Lanz, H. L. et al. Journal of Pharmaceutical Sciences (2021) 110.4: 1601-1614. https://doi.org/10.1016/j.xphs.2021.01.028
- Bircsak, K. M., DeBiasio, R., Miedel, M. et al. Toxicology (2021) 450: 152667. https://doi.org/10.1016/j.tox.2020.152667
- Liu, L., Koo, Y., Akwitti, C. et al. PloS one (2019) 14.11: e0224657. https://doi.org/10.1371/journal.pone.0224657
- Suter-Dick, L., Mauch, L., Ramp, D. et al. The AAPS journal (2018) https://doi.org/10.1208/s12248-018-0245-2
