On-Demand Webinar
In light of the current global pandemic, we are in need of research tools that help us to better understand, treat, and prevent COVID-19. In vitro cell culturing systems like the OrganoPlate® allow the development of organ models that recapitulate the complexities of the in vivo organ. These in vitro models are key to understanding the impact of COVID-19 on organ systems.
In this webinar, dr. Kristin Bircsak (MIMETAS) will review how the OrganoPlate® can be a valuable tool for COVID-19 research.
In this webinar, you will learn:
- How the OrganoPlate® can be used to model target organs of COVID-19, including the kidney, gut, lung and vasculature
- Which assays can be used to assess the functional and physiological properties of these models, such as barrier integrity and monocyte adhesion.
Speaker
Dr. Kristin Bircsak, Principal Scientist at MIMETAS.
Kristin received her Ph.D. in Toxicology in 2016 from Rutgers University following which she completed a postdoctoral fellowship at the University of Pennsylvania. In her training, Kristin utilized various model system to characterize the negative impact of drugs and environmental chemicals on reproduction and development. In her role at MIMETAS, Kristin drives the development of innovative 3D in vitro organotypic models and assays. Her research is centered on recapitulating the liver and prostate tumor microenvironment to aid in the accurate prediction of safe and effective candidate compounds.
Related publications
- Trietsch, S. J., Naumovska, E., Kurek, D. et al. Nature communications (2017) 8.1: 262. https://doi.org/10.1038/s41467-017-00259-3
- Gijzen, L., Yousef Yengej, F. A., Schutgens, F. et al. Nature protocols (2021) 16.4: 2023-2050. https://doi.org/10.1038/s41596-020-00479-w
- Poussin, C., Kramer, B., Lanz, H. L. et al. ALTEX-Alternatives to animal experimentation (2020) 37.1: 47-63. https://doi.org/10.14573/altex.1811301
- Bircsak, K. M., DeBiasio, R., Miedel, M. et al. Toxicology (2021) 450: 152667. https://doi.org/10.1016/j.tox.2020.152667
