• We offer tailored partnerships to support and transform drug discovery.

    Every collaboration is a bespoke arrangement, meticulously designed to discover new compounds and targets in patient relevant disease models.

  • MIMETAS offers flexible fee-for-service solutions for therapy prioritization, optimization, and de-risking of compounds.

    As an extension of your team, MIMETAS provides the expertise and resources needed for effective research and development.

  • Our OrganoReady program is made for you when you need optimized assays for investigational toxicology.

    We guarantee OrganoReady performance according to specifications, in a fast and convenient sales transaction with a clear fee structure.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
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Development of a Glomerulus-on-a-Chip System to Study the Glomerular Filtration Barrier In Vitro

On-Demand Webinar

One of the major roadblocks for the development of successful therapeutics for chronic kidney disease depends on the ability to effectively establish 3D models that can mimic the complex structure and function of the glomerular filtration barrier.

In the majority of the current glomerular models, podocytes and glomerular endothelial cells are separated by a synthetic membrane, equipped with openings (pores) that allow free exchange of media and growth factors, but they do not allow the proper crosstalk between glomerular cells that is key for glomerular filtration barrier function.

To meet this need, researchers from Children’s Hospital Los Angeles (CHLA) developed a glomerulus-on-a-chip model composed of human podocytes and human glomerular endothelial cells in the OrganoPlate®, characterized by the absence of an artificial membrane and direct contact between the two cell types.

In this webinar, you will learn:

  • Challenges of modeling the glomerulus
  • How to replicate a better glomerular architecture devoid of barriers between the endothelial layer and the podocytes
  • Run drug testing on the platform

Register Here


Stefano da Sacco, Assistant Professor at the University of Southern California





Laura Perin, Assistant Professor at the University of Southern California

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