Kidney inflammation plays a central role in many renal diseases, yet traditional in vitro models fall short in capturing the immune complexity and mechanistic insight needed to guide effective therapy development. Our immunocompetent kidney-on-a-chip model addresses this gap by integrating epithelial, endothelial, and immune cell co-culture in a high-throughput microfluidic platform.
Designed to mimic the human proximal tubule, this tri-culture system enables detailed investigation of immune-mediated injury, monocyte migration, and therapeutic modulation. The model also supports donor-specific response profiling, advancing personalized approaches to kidney disease research.
Key Features of the Model
- 3D tri-culture of RPTEC, HUVECs, and human primary monocytes
- Inducible inflammation via complement-activated serum (CAS)
- Quantifiable readouts: ICAM-1 expression, IL-6 release, cell migration
- High-throughput compatible using the OrganoPlate® platform
- Test compound efficacy in modulating renal inflammation and immune cell behavior
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