• We offer tailored partnerships to support and transform drug discovery.

    Every collaboration is a bespoke arrangement, meticulously designed to discover new compounds and targets in patient relevant disease models.

  • MIMETAS offers flexible fee-for-service solutions for therapy prioritization, optimization, and de-risking of compounds.

    As an extension of your team, MIMETAS provides the expertise and resources needed for effective research and development.

  • Our OrganoReady program is made for you when you need optimized assays for investigational toxicology.

    We guarantee OrganoReady performance according to specifications, in a fast and convenient sales transaction with a clear fee structure.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
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Poster: Sorafenib and Lenvatinib Induce Vascular Responses in Patient Derived HCC On-Chip Models

Poster Development of a 3D microphysiological placenta barrier in vitro model as a tool for drug transport studies Hepatocellular carcinoma (HCC) is the most common primary liver cancer accounting for approximately 90% of cases and is strongly associated with chronic liver diseases such as cirrhosis. A biologically relevant, predictive, and user-friendly HCC model is required to expedite research and develop novel therapies.

In this poster, we present the development of a screenable vascularized HCC model in the OrganoPlate® Graft using patient-derived material. This perfusable microvascular network is responsive to standard of care drugs and allows for phenotypic assessment of the vasculature organization. Here, we accomplished high-throughput screening of 30 treatment conditions, including Sorafenib and Lenvatinib, and performed vascular bed- and cytokine analysis.

Download the poster here


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