The blood-brain barrier (BBB) is essential for brain function and ensures a homeostatic environment for the central nervous system (CNS). One of the key objectives of in vitro BBB research is to develop biologically relevant, predictive, and easy-to-use human models that can be used for applications such as toxicity and transport. To achieve this goal, it is necessary to create an in vitro BBB model that is biologically relevant, predictive, and easy-to-use.
In this poster, we present a 3D microfluidic primary human brain microvascular endothelial cell (HBMEC) BBB model with relevant junction and transporter expression, tight and selectively permeable barriers, response to known toxicants, and suitability for high-throughput, on-chip TEER measurements.
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