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  • Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
  • We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
  • Get robust compound data in human tissue models through our services. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
  • We offer several services to support your drug discovery and development needs. Find the overview here.
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    Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.

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  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.

  • Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

  • Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.

  • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

  • The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.

  • OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

  • Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.

    Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.

  • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.

  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Frequently asked questions answered by our experts. Find here the answer you're looking for.
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Poster: Organs-On-Chip Meets High Throughput Screening: Measuring trans-endothelial electrical resistance in an endothelial model

Organs-on-chip meets high throughput screening

Poster Development of a 3D microphysiological placenta barrier in vitro model as a tool for drug transport studies

Barrier function is an important readout in drug development, as the pathogenesis of many human diseases involves tissue barrier disruption, and it can be used to assess the toxic effects of the potential drug compounds. Barrier function can be assessed with Trans Epithelial Electrical Resistance (TEER) measurements. Standard TEER measurements, however, are of low throughput and require an artificial separating membrane, which limits drug permeability and physiological relevance.

In this poster, we present the OrganoTEER®, a device used to perform high throughput TEER measurements in the OrganoPlate® 3-lane. This OrganoPlate platform is based on a 384-microtiter plate which allows for a parallel culture of 40 perfused miniaturized tissues, without the obstruction of artificial membranes. Here, we cultured and analyzed the barrier function of a HUVEC based endothelial model in response to the toxicant staurosporine. The OrganoTEER showed to be a reliable tool in assessing toxic effects in both a time and dose-dependent manner.

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