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  • Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
  • We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
  • Get robust compound data in human tissue models through our OrganoServices. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
  • We offer several services to support your drug discovery and development needs. Find the overview here.
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  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.

  • Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

  • Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.

  • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

  • The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.

  • OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

  • Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.

    Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.

  • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.
  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Frequently asked questions answered by our experts. Find here the answer you're looking for.
  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
EN

Phase 2 funding of £1 million awarded by CRACK IT Challenges to develop TDAR-on-a-chip

Leiden, February 22, 2022 – The CRACK IT Challenges is a competition from the NC3Rs, aimed at funding collaborations between industry, academics, small and medium-sized enterprises. The goal of these projects is to develop innovative solutions into marketable products or services that will deliver 3Rs benefits: the replacement, refinement and reduction of animals in research.

Last February, our team of scientists, which includes Dr. Karla Queiroz and Dr. Michelle Brouwer, was awarded Phase 1 funding of £100,000 for the development of a humanin vitro T-cell dependent antibody response (TDAR) assay. We are proud to announce that this year, the team have been awarded funding of £1 million to deliver Phase 2 of the 2020 CRACK IT Challenges. Other consortium-members include:

  • Professor Jolanda de Vries, Tumor Immunology Radboud
  • Sofie Pattijn, ImmunXperts
  • Jan de Sonneville, Life Science Methods

Why TDAR-on-a-chip?

Their work is sponsored by Bayer AG, GSK, Merck Healthcare KGaA and Novartis Pharma AG, with the the aim of developing a human in vitro TDAR assay to assess the immune enhancement properties of immunomodulatory therapeutics during drug development. A robust in vitro human immune response assay could better predict clinical outcomes and reduce the number of animals used to assess immunotoxicity. 

Having previously carried out proof-of-concept studies during Phase 1, the team will now aim to develop tools to deliver a high-throughput human in vitro t-cell dependent antibody response assay for Phase 2.

Read more about the CRACK IT Challenges.



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