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    • Angiogenesis
      • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

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  • About Mimetas
  • Supporting up to 96 tissue models on a single plate. Its unique PhaseGuide™ technology enables cells to interact and migrate freely between the two channels of each chip.

  • Supporting up to 40 tissue models on a single plate. Its unique PhaseGuide™ technology enables cells to interact and migrate freely between the three channels of each chip.
  • Supporting up to 64 tissue models on a single plate. Specially designed for automated workflows. Its unique PhaseGuide™ technology enables cells to interact and migrate freely between the three channels of each chip.
  • The first in vitro tissue culture platform that allows co-culture of spheroids, organoids, and tumors with a perfused microvascular bed and vascularization of 3D tissues.

  • Offering 38 ready-to-use Caco-2 tubules for drug exposure, transport, and permeability studies.
  • Offering 38 ready-to-use HUVEC tubules for drug exposure, transport, and permeability studies.
  • Offering 64 ready-to-sprout HUVEC tubules.
  • Driving precisely-controlled perfusion flow in the OrganoPlate® platform
  • Enabling fast, automated, and impedance-based TEER measurements in OrganoPlate®. Assay 40 tissue culture chips with a few clicks, in less than one minute.
  • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • OrganoPlate® is the solution for all in vitro tissue culture applications. Explore the entire OrganoPlate® family and its dedicated instruments here.

  • Start with the most sophisticated 3D tissue culture platform today.

  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Get robust compound data in human tissue models through our OrganoServices. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
  • We create novel human tissue and disease models in the OrganoPlate® platform. Our experts are looking forward to developing assays according to your specifications.
  • Expand your drug discovery capacity, shoulder to shoulder with our scientific team. Proprietary human disease biology in the OrganoPlate® platform. Together we make the therapeutics of tomorrow.
  • We offer several services to support your drug discovery and development needs. Find the overview here.
  • Layered tissues with perfused tubules in the absence of artificial membranes form the heart of our permeability and transport science. Study cell interactions, permeability, absorption, transport, and transcytosis without physical barriers.

  • Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

  • Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.

  • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

  • The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.

  • OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

  • Visit our Knowledge Center to get up to speed with 3D tissue culture and to learn how OrganoPlate® supports your research needs.

    Read our publications, application notes, watch our webinars, or check out the supporting protocols and brochures. All compiled for you, by our scientists.

  • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.
  • Thinking of using OrganoPlate for your research? Request a quote for the product(s) of your interest.

  • Frequently asked questions answered by our experts. Find here the answer you're looking for.
  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
EN

MIMETAS partner in €4.5mn EU Interreg project BIOMAT

Engineering 3D microenvironments of vascularized bone and muscle

January 1, 2018 – The objective of the 'Biomat' project is to develop a platform for high-throughput testing of biomaterials in a physiologically relevant environment on-a-chip. The innovative aspects of this platform are a 3D environment that mimics relevant tissues in which novel and existing biomaterials can be integrated for reliable in vitro testing and monitoring.

Bones- and Muscles-on-a-Chip

Within this project, 3D microenvironments of vascularized bone and muscle will be engineered on microfluidic chips and used to test the performance of biomaterials, such as hip implants, bone fillers, and stents. MIMETAS' OrganoPlate® technology offers unique functionalities, not possible with conventional 2D or 3D culture, allowing to better replicate the complex microenvironment of bones and muscles. In addition, MIMETAS' perfused vascular beds, that recapitulate hallmark features of human microvessels, will play an important role in the project.

Within the first two years of the Biomat-on-Microfluidic Chip project, important steps towards creating a new generation of patient-specific organ-on-chip platforms were taken by developing several engineering and biological technologies.

  • First designs and models of the chip have been made in the form of inserts for culture plates. We have succeeded in forming three-dimensional biological micro-constructs of patient-specific cells and various biomaterials at a micron scale. In addition to that, we have developed multiple robust bioassays for screening the toxicity/biocompatibility and the functionality of newly developed biomaterials;
  • Although this 3D model has been tested with human cell lines and stem cells, we have also optimized protocols for differentiating human-induced pluripotent stem cells (hiPSCs) towards muscle and bone tissues and for coupling these cells with reporters with which their growth and metabolism can be monitored non-invasively. Furthermore, we have shown the formation of 3D micro-tissues using these cells;
  • The development of the platform for vascularization of 3D micro-tissues has also been demonstrated;
  • In addition to that, we have developed a sensor that can be coupled to the chip in order to monitor tissue formation overtime;
  • We have developed a technology for the fabrication of micro-biomaterials with different chemistries that can be screened in the platform for biocompatibility and biological functionality.

Partners and Funding

Other partners in the project are: Universiteit Maastricht - MERLN Institute for Technology-Inspired Regenerative Medicine (NL), Katholieke Universiteit Leuven (BE), Xplore Instruments B.V. (NL), Leids Universitair Medisch Centrum (NL), Tenco DDM (BE), DSM R&D Solutions B.V. (NL) and Interuniversitair Micro-Elektronica Centrum - IMEC (BE).

The project was awarded an Interreg Flanders-The Netherlands grant, support from the Dutch Department of Economic Affairs and the Province of Zuid-Holland on a total project budget of €4.5mn.


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