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Whitepaper: High-throughput phenotypic screening with Organ-on-a-chip: a perfused 3D microfluidic angiogenesis assay

Cells in vivo experience a complex, three-dimensional environment that exposes them to circulating molecules, neighboring cells, and the extracellular matrix (ECM). Organ-on-a-Chip is a powerful technology driving physiological relevance by utilizing microfluidic techniques. Organ-on-a-Chip systems aim to mimic cell-matrix and cell-cell interactions, and to recreate physiological compositions and spatial arrangements of cells in vitro.

Since most platform technologies are either based on single chips or small numbers of chips in dedicated surroundings, applications for Organ-on-a-chip are largely envisioned in pre-clinical testing. In this whitepaper, we give a detailed report on a 1546 compound screen on a 3D angiogenic sprouting assay. Download the whitepaper to learn exactly how we used the OrganoPlate® as a high-throughput screening tool. You will also explore how the image-based phenotypic screening offers high-resolution information and generates selective hits and novel biological insights.

 

Download the whitepaper here

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