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  • Get robust compound data in human tissue models through our OrganoServices. With proven pheno­typic assays in the OrganoPlate® platform, we support your drug discovery and development needs.
  • We offer several services to support your drug discovery and development needs. Find the overview here.
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  • Co-culture layered & structured tissues without artificial membranes with perfect imaging, to study barrier-free cellular interactions, cell-cell signaling, and migration.

  • Evaluate the effect of chemotactic triggers or cells on the migration of cells through an extracellular matrix.

  • Membrane-free microvascular formation and growth through an extracellular matrix (ECM).

  • The missing link in tissue culture: add perfusable human vasculature to your tissue models, and recreate sophisticated microenvironments with OrganoPlate® Graft.

  • OrganoPlate® enables you to study relevant 3D tissue biology by incorporating perfused tubules, co-culture, and full control over the tissue microenvironment. Find the overview of applications here.

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  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Kickstart your experiments with the most sophisticated 3D tissue culture platform. Find out which training fits your 3D tissue modeling needs best.
  • Any support questions about purchasing, products, or 3D tissue culture and analysis? Get in touch with our experts.
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App Note: Building a High-throughput and Automated Liver-on-a-chip Model for Hepatotoxicity Detection

Drug induced liver injury (DILI) is the leading cause of approved drug withdrawal from the market and presents a major health concern as more than 50% of acute liver failures are caused by DILI. Identification of hepatotoxic compounds in the preclinical phase of drug development is key to preventing DILI, however currently employed animal and two-dimensional (2D) in vitro models often fail to predict clinical hepatotoxicity.

Physiologically relevant and efficient in vitro models that mimic the human liver microenvironment and clinical outcome are necessary. Microphysiological system (MPS) models of the liver, or liver-on-a-chip models, incorporate principal characteristics of the in vivo liver such as 3D structure, co-culture, and perfusion. However, many MPS liver models require complex assembly and therefore are low- throughput, limiting their use in a drug screening capacity.

In this application note, we demonstrate the development and assessment of a 3D microfluidic liver-on-a-chip model in the OrganoPlate®, ready to be used for high-throughput hepatotoxicity screening: the OrganoPlate LiverToxTM.

Benefits of the model:

  • A robust and validated liver-on-a-chip model to use for high-throughput hepatotoxicity screening
  • Recapitulate the in vivo liver through a 3D three liver-cell type model, without the use of animals
  • Perform a compound library screen to assess, rank, and prioritize compounds for follow-up mechanistic studies

Want to learn more? Download the app note below!

 

Download the app note here

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