Cell migration is an essential process for many biological phenomena such as early embryonic developmentand immune cell response. During inflammation, the recruitment and migration of T cells through the vascular system towards the site of inflammation is a crucial component.
In this app note, we demonstrate the development of an in vitro assay utilizing the OrganoPlate® platform to study T cell dynamics in combination with a blood vessel structure under perfused condition, as well as the high-content imaging used to observe migration of cells at various time points.
Benefits of the model:
- Create complex cell migration assays that are easily scalable and compatible for high-content imaging
- Perform quantitative assessment of immune cell dynamics, generating high throughput readouts such as cell numbers and cell migration distance
Want to learn more? Download the app note below!
Download the app note here