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App Note: 3D Immune Cell Migration

Cell migration is an essential process for many biological phenomena such as early embryonic development and immune cell response. During inflammation, the recruitment and migration of T cells through the vascular system towards the site of inflammation is a crucial component.

In this app note, we demonstrate the development of an in vitro assay utilizing the OrganoPlate® platform to study T cell dynamics in combination with a blood vessel structure under perfused conditions, as well as the high-content imaging used to observe the migration of cells at various time points.

Benefits of the model:

  • Create complex cell migration assays that are easily scalable and compatible for high-content imaging
  • Perform quantitative assessment of immune cell dynamics, generating high throughput readouts such as cell numbers and cell migration distance


Download the app note here


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