The establishment of physiologically relevant in vitro models is crucial to further understanding the mechanisms of neurological diseases as well as targeted drug development. While iPSC-derived neurons show great promise for compound screening and disease modeling, the use of three-dimensional (3D) structures is emerging as a valid approach for neuronal cell-based assay development. 3D cultures are recognized as more closely recapitulating aspects of the human tissues including the architecture, cell organization, as well as cell-cell and cell-matrix interactions. That is why we have developed a high-throughput 3D neurite outgrowth assay using iPSC-derived neurons developed in the OrganoPlate® platform.
The benefits of the model:
- Establish a high-throughput 3D neurite outgrowth assay using iPSC-derived neurons
- Generate more in vivo-line results using the microfluidic OrganoPlate® platform
- Optimize high-content imaging for evaluation of treatment effect on neuronal networks
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