Chat with us, powered by LiveChat
  • Get inspired by peer-reviewed publications of our scientists, partners, and customers around the globe.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
open menu icon close menu icon
EN

App Note: Transendothelial Migration of T Cells in A Microfluidic 3D Endothelium-on-a-Chip Model

One of the crucial steps in the human immune response is the migration of T cells from an endothelial vessel into the surrounding tissue. If this process is aberrant, it could lead to an improper immune response due to a lack of T cells, or chronic inflammation in excess of T cells, which makes it an important aspect of study.

Whereas in vivo models suffer from a lack of translational value and increasing ethical debate, simplified in vitro models lack vasculature, extracellular matrix (ECM), and neighboring cells, leading to suboptimal research models. Organ-on-a-chip models can provide valuable solutions to these issues.

In this application note we show our newly developed T cell perfused endothelium on a chip model to study transendothelial migration of T cells towards chemotactic triggers and tumor cells.


Benefits of the model:

  • A robust and endothelium-on-a-chip model to study T cell migration in the absence of artificial membranes
  • Induction of T cell migration based on a chemotactic trigger and tumor cells
  • Suitable for high throughput screening of migration inducing or inhibiting compounds

 

Download the app note here

Cookies

‘May we use cookies?
Hi there! Thanks for visiting our website. We use cookies to keep track of our website statistics to optimize the user experience. We also use cookies for marketing purposes. You can set your preferences by selecting the options below. Terms of Use & Privacy Policy

Accept all
Accept selected
Decline all