• We offer tailored partnerships to support and transform drug discovery.

    Every collaboration is a bespoke arrangement, meticulously designed to discover new compounds and targets in patient relevant disease models.

  • MIMETAS offers flexible fee-for-service solutions for therapy prioritization, optimization, and de-risking of compounds.

    As an extension of your team, MIMETAS provides the expertise and resources needed for effective research and development.

  • Our OrganoReady program is made for you when you need optimized assays for investigational toxicology.

    We guarantee OrganoReady performance according to specifications, in a fast and convenient sales transaction with a clear fee structure.

  • Giving you some food for thought. Read our blogs to learn more about 3D tissue culture, research backgrounds, developments, and its future outlook.
  • Get inspired by research done by our scientists, partners, and customers around the globe.

  • Learn about our mission, vision, the history of the company, and find out what we mean with MIMETAS-do.
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App Note: Transendothelial Migration of T Cells in A Microfluidic 3D Endothelium-on-a-Chip Model

One of the crucial steps in the human immune response is the migration of T cells from an endothelial vessel into the surrounding tissue. If this process is aberrant, it could lead to an improper immune response due to a lack of T cells, or chronic inflammation in excess of T cells, which makes it an important aspect of study.

Whereas in vivo models suffer from a lack of translational value and increasing ethical debate, simplified in vitro models lack vasculature, extracellular matrix (ECM), and neighboring cells, leading to suboptimal research models. Organ-on-a-chip models can provide valuable solutions to these issues.

In this application note we show our newly developed T cell perfused endothelium on a chip model to study transendothelial migration of T cells towards chemotactic triggers and tumor cells.

Benefits of the model:

  • A robust and endothelium-on-a-chip model to study T cell migration in the absence of artificial membranes
  • Induction of T cell migration based on a chemotactic trigger and tumor cells
  • Suitable for high throughput screening of migration inducing or inhibiting compounds


Download the app note here


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