Transendothelial Migration of T Cells in A Microfluidic 3D Endothelium-on-a-Chip Model
One of the crucial steps in the human immune response is the migration of T cells from an endothelial vessel into the surrounding tissue. If this process is aberrant, it could lead to an improper immune response due to a lack of T cells, or chronic inflammation in excess of T cells, which makes it an important aspect of study.Whereas in vivo models suffer from a lack of translational value and increasing ethical debate, simplified in vitro models lack vasculature, extracellular matrix (ECM), and neighboring cells, leading to suboptimal research models. Organ-on-a-chip models can provide valuable solutions to these issues.In this application note we show our newly developed T cell perfused endothelium on a chip model to study transendothelial migration of T cells towards chemotactic triggers and tumor cells.Benefits of the model:A robust and endothelium-on-a-chip model to study T cell migration in the absence of artificial membranesInduction of T cell migration based on a chemotactic trigger and tumor cellsSuitable for high throughput screening of migration inducing or inhibiting compounds
Transendothelial Migration of T Cells in A Microfluidic 3D Endothelium-on-a-Chip Model
Transendothelial Migration of T Cells in A Microfluidic 3D Endothelium-on-a-Chip Model
A physiologically relevant 3D migration model: The endothelium-on-a-chip system enables high-throughput analysis of T cell transendothelial migration in response to chemotactic and tumor-derived triggers using perfused vessels and standard lab equipment.
Transendothelial Migration of T Cells in A Microfluidic 3D Endothelium-on-a-Chip Model
A physiologically relevant 3D migration model: The endothelium-on-a-chip system enables high-throughput analysis of T cell transendothelial migration in response to chemotactic and tumor-derived triggers using perfused vessels and standard lab equipment.
Transendothelial Migration of T Cells in A Microfluidic 3D Endothelium-on-a-Chip Model
A physiologically relevant 3D migration model: The endothelium-on-a-chip system enables high-throughput analysis of T cell transendothelial migration in response to chemotactic and tumor-derived triggers using perfused vessels and standard lab equipment.
Transendothelial Migration of T Cells in A Microfluidic 3D Endothelium-on-a-Chip Model
A physiologically relevant 3D migration model: The endothelium-on-a-chip system enables high-throughput analysis of T cell transendothelial migration in response to chemotactic and tumor-derived triggers using perfused vessels and standard lab equipment.
Transendothelial Migration of T Cells in A Microfluidic 3D Endothelium-on-a-Chip Model
A physiologically relevant 3D migration model: The endothelium-on-a-chip system enables high-throughput analysis of T cell transendothelial migration in response to chemotactic and tumor-derived triggers using perfused vessels and standard lab equipment.
Transendothelial Migration of T Cells in A Microfluidic 3D Endothelium-on-a-Chip Model
A physiologically relevant 3D migration model: The endothelium-on-a-chip system enables high-throughput analysis of T cell transendothelial migration in response to chemotactic and tumor-derived triggers using perfused vessels and standard lab equipment.
Transendothelial Migration of T Cells in A Microfluidic 3D Endothelium-on-a-Chip Model
A physiologically relevant 3D migration model: The endothelium-on-a-chip system enables high-throughput analysis of T cell transendothelial migration in response to chemotactic and tumor-derived triggers using perfused vessels and standard lab equipment.
Transendothelial Migration of T Cells in A Microfluidic 3D Endothelium-on-a-Chip Model
A physiologically relevant 3D migration model: The endothelium-on-a-chip system enables high-throughput analysis of T cell transendothelial migration in response to chemotactic and tumor-derived triggers using perfused vessels and standard lab equipment.