OrganoPlate® Graft | Mimetas

OrganoPlate® Graft

OrganoPlate® Graft

The OrganoPlate Graft®

The OrganoPlate® Graft is the first in vitro cell culture platform that allows vascularization of 3D tissues like spheroids, organoids, and tumors in vitro.

The OrganoPlate® Graft incorporates the unique technology developed by MIMETAS to grow functional microvessels in a chip to create a microvascular bed.

Tissue placed onto this bed is connected to the system of human blood vessels, achieving in vitro vascularization. This uniquely facilitates perfusion of the tissue and allows drug administration through the vasculature.

via GIPHY

Features and Benefits

Benefits of OrganoPlate Graft
Features of OrganoPlate Graft
  • Vascularized 3D tissues
    • Internal perfusion of solid tissue samples
    • Add perfusable human vasculature to your tissue models
    • Recreate sophisticated microenvironments
  • Multiple tissue sources
    • Organoids, tumor explants, spheroids and more
    • Pump-free perfused vessels
      • Hassle-free, low investment
    • Apical and basal access to vessels
      • A wide range of biological applications
      • Direct access to your vascularized material

    Furthermore, the OrganoPlate Graft comes in a microtiter plate format. For you, this means compatibility with all your lab equipment and easiness in starting using it. The microscopy grade glass bottom allows you to capture images of the highest quality, and because no PDMS is used to make the chips, compounds absorption will stay minimal.

    You can use up to 64 chips to grow your models, making the OrganoPlate Graft suitable for medium/high throughput experiments.

    Supported Tissue Models

    Kidney organoids in the OrganoPlate Graft®

    Functional blood vessels are a vital connecting structure inside the body (‘in vivo’). This aspect is lacking in all the currently available in vitro cell culture techniques, until now.

    The OrganoPlate Graft is made for grafting tissues to a vascular bed.  You can achieve this in three three steps:

    1. Grow blood vessels
    2. Grow vascular bed
    3. Place tissue on vascular bed

    This product can be used for vascularization studies of tissues (organoids, spheroids, and PDX material) in areas such as oncology, toxicology, 

    Vascularized Cancer Tissue

    Ovary and breast cancer explants

    You can mimic the tumor microenvironment in vitro by grafting (PDX) tumor tissue in a 3D natural tissue environment. A well-defined co-culture system can include vasculature, and 2 to 3 main components of the tumor microenvironment to increase the physiological relevance of the model.

    Get Started

    The OrganoPlate Graft will be released in Q3 2019.

    Do you want to learn more or want to be informed when the product becomes available? Fill in the form below to request more information. One of our representatives will get back to you within 24 hours.

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