On-demand Webinar
Inflammation is an essential mechanism that helps fight off acute infections. The vasculature plays an integral role in inflammatory processes by moving around and transporting different types of cells, such as immune cells, chemokines and cytokines. Chronic inflammation may increase the risk of cardiovascular diseases, such as atherosclerosis and endothelial dysfunction, by having an effect on the endothelium which influences functions such as vascular tone and barrier integrity. To screen targets and develop drugs to treat chronic vascular inflammation, it is critical to create models that recapitulate changes in vascular barrier permeability in inflammatory conditions as well as develop methods to accurately quantify the model’s barrier integrity.
Organ-on-chip technology has facilitated the development of 3D vasculature in vitro models that have allowed the incorporation of key mechanical, chemical and biological factors. Join us this June 20th and see how the OrganoPlate® was used to model immune cell interaction in endothelial inflammation to establish a model ideal for routine target screening towards the treatment of chronic vascular inflammation.
In this webinar, you will:
- Discover the high-throughput of the OrganoPlate platform and its compatibility to multiplex multiple assays
- Learn how we utilized the OrganoPlate to model vascular inflammation to study cardiovascular diseases
- Explore real-time barrier resistance measurements using the OrganoTEER® to detect small changes in barrier in response to inflammatory stimuli
Watch the webinar here
Speakers
Haley Ehlers is a Marie Sklodowska-Curie fellow at the LogicLab consortium and Early-Stage Researcher
affiliated with MIMETAS. Previously, she studied biomedical engineering, specializing in regenerative medicine at California Polytechnic State University, in California, USA. In her current role, she focuses on establishing and developing arterial models in the OrganoPlate, MIMETAS high throughput organ-on-chip platform.
Arya Lekshmi Nair is a Marie Sklodowska-Curie fellow at the Entrain consortium and Early Stage Researcher affiliated with MIMETAS. She received her Bachelor's Degree in Biomedical Engineering from SRM University, India and her Master's Degree in Biomedical Technologies from Eberhard Karls University of Tübingen, Germany. At MIMETAS, she focuses on establishing and developing human blood-brain barrier and neurovascular unit models in the OrganoPlate.
